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The Lewis-Sigler Institute for Integrative Genomics, housed in the Carl Icahn Laboratory at Princeton University, was established to innovate in research and teaching at the interface of modern biology and the more quantitative sciences. The Institute is the hub of the Center for Quantitative Biology, funded by the National Institute of General Medical Sciences (NIGMS), one of the National Institutes of Health (NIH). We are currently accepting applications to our Lewis-Sigler Fellows program. Seminars Lewis-Sigler Institute 2009-2010 Quantitative and Computational Biology Seminar Series (view upcoming seminars) Next seminar: Monday, February 15, 2010 (4:15 PM, 101 Carl Icahn Laboratory) Joe Thornton , University of Oregon Evolution of steroid hormone receptors: contingency and complexity in protein evolution Integrated Science Shorts Series Next seminar: Tuesday, February 16, 2010 (4:30 PM, 101 Carl Icahn Laboratory) Simon F. Nørrelykke / Erin Haley, Cox Group / Coller Group Haley - Silence of the Cells: Self-Cannibalism and Survival of Quiescent Fibroblasts Nørrelykke - Deaf, dumb, and blind: How amoebae find their food Other Upcoming Seminars at the Institute Next seminar: There are no upcoming seminars. View past seminars. Home and Away: Harvard-Princeton NIGMS Centers Seminars Next seminar: Tuesday, February 09, 2010 (4:30 PM, 101 Carl Icahn Laboratory) Kevin Wood , Harvard University FAS Center for Systems Biology Cost and Benefit Govern Drug Interactions in Bacterial Multi-antibiotic Resistance Biophysics Seminar Series (view upcoming seminars) Hosted by the Department of Physics and the Lewis-Sigler Institute Next seminar: Monday, March 01, 2010 (12:00 PM, Joseph Henry Room, Jadwin) Elio Abbondanzieri , Harvard University Title to be announced... View past seminars. News Tavazoie research team shows how cancerous cells "go wrong" 12/10/2009 - A research team led by Saeed Tavazoie, professor of Molecular Biology and the Lewis-Sigler Institute, has produced a systematic listing of the ways a particular cancerous cell has "gone wrong," giving researchers a powerful tool that eventually could make possible new, more targeted therapies for patients. Writing in the Dec. 11 issue of Molecular Cell, Tavazoie, along with his colleagues Hani Goodarzi, a graduate student in molecular biology, and Olivier Elemento, a former postdoctoral researcher in the Institute, found they were able to systematically categorize and pinpoint the alterations in cancer pathways and to reveal the underlying regulatory code in DNA. (Read more) Damon Runyon Fellowship awarded to Llinás lab postdoctoral fellow 11/23/2009 - Björn F.C. Kafsack, a postdoctoral fellow in the Llinás lab, has been awarded a fellowship from the Damon Runyon Cancer Institute. This three-year award will fund his proposal titled "Density-Dependent Autocrine Control of Gametocytogenesis in the virulent malaria parasite Plasmodium falciparum." The goal of this work is to identify the molecular determinants that are sensed by the malaria parasite and how they trigger development of the sexual gametocyte stage. To accomplish this, he will use a metabolomics-based approach to determine the identity of soluble small-molecule mediators of this transition, which will be further characterized to understand the regulatory pathways responsible for cell-based communication. ISI ScienceWatch features John Storey in Fast Moving Fronts article 11/16/2009 - A November article on ScienceWatch.com discusses a highly cited 2005 paper by Associate Professor of Molecular Biology and member of the Lewis-Sigler Institute for Integrative Genomics, John Storey, and colleagues. The paper, titled "Significance analysis of time course microarray experiments," was published in the Proceedings of the National Academies of Science, and provided a groundbreaking statistical approach for analyzing gene expression studies carried out over a period of time. News Archive Last updated: Copyright © 2007 Lewis-Sigler Institute for Integrative Genomics. Princeton University. All Rights Reserved.