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Publications 
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  1. Hess DC, Lu W, Rabinowitz JD, Botstein D. Ammonium Toxicity and Potassium Limitation in Yeast. PLoS Biol. 2006 Oct 17;4(11) PDF link
  2. Fisk DG, Ball CA, Dolinski K, Engel SR, Hong EL, Issel-Tarver L, Schwartz K, Sethuraman A, Botstein D, Cherry JM, The Saccharomyces Genome Database Project. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Yeast. 2006 Sep;23(12):857-65. PDF link
  3. Wingreen N, Botstein D. Back to the future: education for systems-level biologists. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):829-32. PDF link
  4. Heck JA, Gresham D, Botstein D, Alani E. Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements. Genetics. 2006 Sep; 174(1):519-23. PDF link
  5. Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, Tong A, Stark C, Ho Y, Botstein D, Andrews B, Boone C, Troyanskya OG, Ideker T, Dolinski K, Batada NN, Tyers M. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J Biol. 2006;5(4):11. PDF link
  6. Botstein, D. Willing to do the math: an interview with David Botstein. Inverview by Jane Gitschier. PLoS. 2006 May;2(5):e79. PDF link
  7. Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham M, Botstein D, Kruglyak L. Genome-wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray. Science. 2006 Mar 31;311(5769):1932-6. PDF link
  8. Diehn M, Bhattacharya R, Botstein D, Brown PO. Genome-Scale Identification of Membrane-Associated Human mRNAs. PLoS Genet. 2006 Jan 13;2(1):e11PDF link
  9. Hirschman JE, Balakrishnan R, Christie KR, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hong EL, Livstone MS, Nash R, Park J, Oughtred R, Skrzypek M, Starr B, Theesfeld CL, Williams J, Andrada R, Binkley G, Dong Q, Lane C, Miyasato S, Sethuraman A, Schroeder M, Thanawala MK, Weng S, Dolinski K, Botstein D, Cherry JM. Genome Snapshot: a new resource at the Saccharomyces Genome Database (SGD) presenting an overview of the Saccharomyces cerevisiae genome. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D442-5.PDF link
  10. Ronen M, Botstein D. Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):389-94. PDF link
  11. Dolinski K, Botstein D. Changing perspectives in yeast research nearly a decade after the genome sequence. Genome Res. 2005 Dec;15(12):1611-9. Review.PDF link
  12. Balakrishnan R, Christie KR, Costanzo MC, Dolinski K, Dwight SS, Engel SR, Fisk DG, Hirschman JE, Hong EL, Nash R, Oughtred R, Skrzypek M, Theesfeld CL, Binkley G, Dong Q, Lane C, Sethuraman A, Weng S, Botstein D, Cherry JM. (2005) Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Nucleic Acids Res. 33: D374-7. PDF link
  13. Wang W, Cherry JM, Nochomovitz Y, Jolly E, Botstein D, Li H. (2005) Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation. Proc Natl Acad Sci (USA). 102: 1998-2003. PDF link
  14. Brauer MJ, Saldanha AJ, Dolinski K, Botstein D. (2005) Homeostatic Adjustment and Metabolic Remodeling in Glucose-limited Yeast Cultures. Mol Biol Cell. 16: 2503-17PDF link
  15. Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA. (2005) Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci (USA). 102: 5814-9. PDF link
  16. Shyamsundar R, Kim YH, Higgins JP, Montgomery K, Jorden M, Sethuraman A, van de Rijn M, Botstein D, Brown PO, Pollack JR. (2005) A DNA microarray survey of gene expression in normal human tissues. Genome Biol. 6: R22. PDF link
  17. Trinklein ND, Murray JI, Hartman SJ, Botstein D, Myers RM. (2004) The Role of Heat Shock Transcription Factor 1 in the Genome-wide Regulation of the Mammalian Heat Shock Response.PDF link
  18. Shakoury-Elizeh M, Tiedeman J, Rashford J, Ferea T, Demeter J, Garcia E, Rolfes R, Brown PO, Botstein D, Philpott CC. (2004) Transcriptional Remodeling in Response to Iron Deprivation in Saccharomyces cerevisiae. Mol Biol Cell. 15: 1233-43. PDF link
  19. Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, Richter J, Rubin GM, Blake JA, Bult C, Dolan M, Drabkin H, Eppig JT, Hill DP, Ni L, Ringwald M, Balakrishnan R, Cherry JM, Christie KR, Costanzo MC, Dwight SS, Engel S, Fisk DG, Hirschman JE, Hong EL, Nash RS, Sethuraman A, Theesfeld CL, Botstein D, Dolinski K, Feierbach B, Berardini T, Mundodi S, Rhee SY, Apweiler R, Barrell D, Camon E, Dimmer E, Lee V, Chisholm R, Gaudet P, Kibbe W, Kishore R, Schwarz EM, Sternberg P, Gwinn M, Hannick L, Wortman J, Berriman M, Wood V, de la Cruz N, Tonellato P, Jaiswal P, Seigfried T, White R; (2004) Gene Ontology Consortium. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res. 32.PDF link
  20. Christie KR, Weng S, Balakrishnan R, Costanzo MC, Dolinski K, Dwight SS, Engel SR, Feierbach B, Fisk DG, Hirschman JE, Hong EL, Issel-Tarver L, Nash R, Sethuraman A, Starr B, Theesfeld CL, Andrada R, Binkley G, Dong Q, Lane C, Schroeder M, Botstein D, Cherry JM. (2004) Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms. Nucleic Acids Res. 32 PDF link
  21. Lapointe J, Li C, Higgins JP, van de Rijn M, Bair E, Montgomery K, Ferrari M, Egevad L, Rayford W, Bergerheim U, Ekman P, DeMarzo AM, Tibshirani R, Botstein D, Brown PO, Brooks JD, Pollack JR. (2004) Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci (USA) 101: 811-6. PDF link
  22. Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, Rijn Mv M, Botstein D, Brown PO. (2004) Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds. PLoS Biol. 2004; 2: E7.PDF link
  23. Murray JI, Whitfield ML, Trinklein ND, Myers RM, Brown PO, Botstein D. (2004) Diverse and specific gene expression responses to stresses in cultured human cells. Mol Biol Cell. 15: 2361-74.PDF link
  24. Lossos IS, Czerwinski DK, Alizadeh AA, Wechser MA, Tibshirani R, Botstein D, Levy R. Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. (2004)PDF link
  25. Zhao H, Langerod A, Ji Y, Nowels KW, Nesland JM, Tibshirani R, Bukholm IK, Karesen R, Botstein D, Borresen-Dale AL, Jeffrey SS.. (2004) Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell. 15: 2523-36.PDF link
  26. Saldanha AJ, Brauer MJ, Botstein D. (2004) Nutritional homeostasis in batch and steady-state culture of yeast. Mol Biol Cell. 15: 4089-104. PDF link
  27. Shapira M, Segal E, Botstein D. (2004) Disruption of Yeast Forkhead-associated Cell Cycle Transcription by Oxidative Stress. Mol Biol Cell. 15: 5659-69.PDF link
  28. Rees CA, Demeter J, Matese JC, Botstein D, Sherlock G. (2004) GeneXplorer: an interactive web application for microarray data visualization and analysis. BMC Bioinformatics 5: 141.PDF link
  29. Tu IP, Schaner M, Diehn M, Sikic BI, Brown PO, Botstein D, Fero MJ. (2004) A method for detecting and correcting feature misidentification on expression microarrays. BMC Genomics 5: 64. PDF link
  30. Bialek W, Botstein D. (2004) Introductory science and mathematics education for 21st-Century biologists. Science. ;303: 788-90. PDF link
  31. Botstein, D., (2004) Genomic perspective and cancer. Cold Spring Harb Symp Quant Biol.;68:417-24PDF link
  32. Botstein, D., (2004) Ira Herskowitz: 1946-2003. Genetics 166:653-60PDF link
  33. Diehn M, Sherlock G, Binkley G, Jin H, Matese JC, Hernandez-Boussard T, Rees CA, Cherry JM, Botstein D, Brown PO, Alizadeh AA. (2003) SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data. Nucleic Acids Res.; 31: 219-23. PDF link
  34. Ranade K, Hinds D, Hsiung CA, Chuang LM, Chang MS, Chen YT, Pesich R, Hebert J, Chen YD, Dzau V, Olshen R, Curb D, Botstein D, Cox DR, Risch N. (2003). A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. Am J Hypertens. 16: 158-62. PDF link
  35. Bohen SP, Troyanskaya OG, Alter O, Warnke R, Botstein D, Brown PO, Levy R. (2003) Variation in gene expression patterns in follicular lymphoma and the response to rituximab. Proc Natl Acad Sci (USA) 100:1926-30. PDF link
  36. Alter O, Brown PO, Botstein D. (2003). Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms. Proc Natl Acad Sci (USA). 100: 3351-6. PDF link
  37. McInnis MG, Lan TH, Willour VL, McMahon FJ, Simpson SG, Addington AM, MacKinnon DF, Potash JB, Mahoney AT, Chellis J, Huo Y, Swift-Scanlan T, Chen H, Koskela R, Colin Stine O, Jamison KR, Holmans P, Folstein SE, Ranade K, Friddle C, Botstein D, Marr T, Beaty TH, Zandi P, Raymond DePaulo J. (2003) Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. Mol Psychiatry. 8: 288-98. PDF link
  38. Segal E, Shapira M, Regev A, Pe'er D, Botstein D, Koller D, Friedman N. (2003) Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet. 34: 166-76. PDF link
  39. Troyanskaya OG, Dolinski K, Owen AB, Altman RB, Botstein D. (2003) A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae). Proc Natl Acad Sci (USA). 100: 8348-53. PDF link
  40. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci (USA); 100: 8418-8423. PDF link
  41. Chen X, Leung SY, Yuen ST, Chu KM, Ji J, Li R, Chan AS, Law S, Troyanskaya OG, Wong J, So S, Botstein D, Brown PO. (2003) Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 14: 3208-15. PDF link
  42. Linn SC, West RB, Pollack JR, Zhu S, Hernandez-Boussard T, Nielsen TO, Rubin BP, Patel R, Goldblum JR, Siegmund D, Botstein D, Brown PO, Gilks CB, Van De Rijn M. (2003) Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans. Am J Pathol. 163: 2383-95. PDF link
  43. Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. (2003) T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression. PLoS Biol. 1: E53. PDF link
  44. Zhao H, Whitfield ML, Xu T, Botstein D, Brooks JD. (2003) Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells. Mol Biol Cell. 15: 506-19PDF link
  45. Smith KS, Chanda SK, Lingbeek M, Ross DT, Botstein D, van Lohuizen M, Cleary ML. (2003) Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Mol Cell. 12: 393-400. PDF link
  46. Whitfield ML, Finlay DR, Murray JI, Troyanskaya OG, Chi JT, Pergamenschikov A, McCalmont TH, Brown PO, Botstein D, Connolly MK. (2003) Systemic and cell type-specific gene expression patterns in scleroderma skin. Proc Natl Acad Sci (USA). 100: 12319-24. PDF link
  47. Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M. (2003) Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am J Pathol. 163: 1449-56. PDF link
  48. Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO.(2003) Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci (USA) 100: 10623-8.PDF link
  49. Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O'Dwyer PJ, Fero MJ, Kristensen GB, Borresen-Dale AL, Hastie T, Tibshirani R, Van De Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO, Sikic BI. (2003) Gene expression patterns in ovarian carcinomas. Mol Biol Cell. 14: 4376-86. PDF link
  50. Gollub J, Ball CA, Binkley G, Demeter J, Finkelstein DB, Hebert JM, Hernandez-Boussard T, Jin H, Kaloper M, Matese JC, Schroeder M, Brown PO, Botstein D, Sherlock G. The Stanford Microarray Database: data access and quality assessment tools. Nucleic Acids Res. (2003) Jan 1;31(1):94-6. PDF link
  51. Weng S, Dong Q, Balakrishnan R, Christie K, Costanzo M, Dolinski K, Dwight SS, Engel S, Fisk DG, Hong E, Issel-Tarver L, Sethuraman A, Theesfeld C, Andrada R, Binkley G, Lane C, Schroeder M, Botstein D, Michael Cherry J. Saccharomyces Genome Database (SGD) provides biochemical and structural information for budding yeast proteins. Nucleic Acids Res. (2003) Jan 1;31(1):216-8. PDF link
  52. Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet. (2003) Mar;33 Suppl:228-37. Review. PDF link
  53. Uhlmann WR, Bennett R, Botkin JR, Botstein D, Boughman JA, Chakravarti A, Clayton EW, Kahn J, Koenig B, Murray TH, Olson MV, Rowley J, Terry S, Valle D. Planning the genome institute's future. Science. (2003) Mar 7;299 5612:1515PDF link
  54. Boldrick, J.C., Alizadeh, A.A., Diehn, M., Dudoit, S., Liu, C.L., Belcher, C. E., Botstein, D., Staudt, L.M., Brown, P.O., Relman, D. A., (2002) Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc. Natl. Acad.Sci. USA 99: 972-977 .PDF link
  55. Ranade, K., Jorgenson, E., Shew, W.H. , Pei, D., Hsiung, C.A., Chiang, F., Chen,Y.I., Pratt, R., Olshen, R. A., Curb, D., Cox, D. R., Botstein, D., Risch, N. (2002) A Polymorphism in the _1 Adrenergic Receptor Is Associated with Resting Heart Rate. Am. J. Hum. Genet 70: 935-42.PDF link
  56. Click, E.S., Stearns, T and Botstein, D. (2002) Systematic Structure-Function Analysis of the Small GTPase Arf1 in Yeast. Mol. Biol. Cell. 13: 1652-64.PDF link
  57. Nielsen, T.O., West, R.B., Linn, S.C., Alter, O., Knowling, M.A., O'Connell, J.X., Zhu, S., Fero, M., Sherlock, G., Pollack, J.R., Brown, P.O., Botstein, D., van de Rijn, M. (2002) Molecular characterisation of soft tissue tumours: a gene expression study Lancet 359: 1301-7PDF link
  58. Ranade K, Jorgenson E, Sheu WH, Pei D, Hsiung CA, Chiang FT, Chen YD, Pratt R, Olshen RA, Curb D, Cox DR, Botstein D, Risch N. (2002) A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet. 70: 935-42PDF link
  59. Yoshimoto H, Saltsman K, Gasch AP, Li HX, Ogawa N, Botstein D, Brown PO, Cyert MS. (2002) Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae. J Biol Chem. 277: 31079-88. PDF link
  60. Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, Van De Rijn M, Botstein D, Brown PO. (2002) Gene expression patterns in human liver cancers. Mol Biol Cell. 3: 1929-39. PDF link
  61. Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, Matese JC, Perou CM, Hurt MM, Brown PO, Botstein D. (2002) Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell. 13: 1977-2000. PDF link
  62. Lossos IS, Alizadeh AA, Diehn M, Warnke R, Thorstenson Y, Oefner PJ, Brown PO, Botstein D, Levy R. (2002) Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci (USA) 99:8886-91.PDF link
  63. Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ. (2002) Transcriptional response of human mast cells stimulated via the Fcϵ RI and identification of mast cells as a source of IL-11. BMC Immunol. 3:5. PDF link
  64. Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO. (2002) Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A.;99: 11796-801. Erratum in: Proc Natl Acad Sci U S A; 99:15245.PDF link
  65. Trotter EW, Kao CM, Berenfeld L, Botstein D, Petsko GA, Gray JV. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. J Biol Chem. ; 277: 44817-25. PDF link
  66. Pollack JR, Sorlie T, Perou CM, Rees CA, Jeffrey SS, Lonning PE, Tibshirani R, Botstein D, Borresen-Dale AL, Brown PO. (2002) Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci (USA) 99: 12963-8. PDF link
  67. Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO. (2002) Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci (USA) 99:12877-82. PDF link
  68. Troyanskaya OG, Garber ME, Brown PO, Botstein D, Altman RB. (2002) Nonparametric methods for identifying differentially expressed genes in microarray data. Bioinformatics 18:1454-61. PDF link
  69. Dunham MJ, Badrane H, Ferea T, Adams J, Brown PO, Rosenzweig F, Botstein D. (2002) Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae. Proc Natl Acad Sci (USA) 99: 16144-9. PDF link
  70. Leung SY, Chen X, Chu KM, Yuen ST, Mathy J, Ji J, Chan AS, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D, Brown PO. (2002) Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A.; 99: 16203-8. PDF link
  71. van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Kochli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, Brown P. (2002) Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome. J Pathol. 161: 1991-6.PDF link
  72. Wang W, Cherry JM, Botstein D, Li H. (2002) A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae. Proc Natl Acad Sci (USA) 99: 16893-8. PDF link
  73. Dwight, S.S., Harris, M.A., Dolinski, K., Ball, C.A., Binkley, G., Christie, K.R., Fisk, D. G., Issel-Tarver, L., Schroeder, M., Sherlock, G., Sethuraman, A., Weng, S., Botstein, D, Cherry, J. M. (2002) Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO). Nucleic Acids Res. 30:69-72.PDF link
  74. Pollack JR, Van de Rijn M, Botstein D. Challenges in developing a molecular characterization of cancer. Semin Oncol. (2002) Jun;29(3):280-5. Review.PDF link
  75. Issel-Tarver L, Christie KR, Dolinski K, Andrada R, Balakrishnan R, Ball CA, Binkley G, Dong S, Dwight SS, Fisk DG, Harris M, Schroeder M, Sethuraman A, Tse K, Weng S, Botstein D, Cherry JM. Saccharomyces Genome Database. Methods Enzymol. (2002);350:329-46. PDF link
  76. Mulholland J, Botstein D. Immunoelectron microscopy of aldehyde-fixed yeast cells. Methods Enzymol. (2002);351:50-81. PDF link
  77. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling. Overview of the Alliance for Cellular Signaling. Nature. (2002) Dec 12; 420: 703-6 PDF link
  78. Carmel-Harel, O., R. Stearman, A. P. Gasch, D. Botstein, P. O. Brown, and G. Storz (2001). Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae Mol. Microbiol. 39: 595-605. PDF link
  79. Hastie, T., R. Tibshirani, D. Botstein, and P. Brown (2001). Supervised harvesting of expression trees Genome Biol. 2.PDF link
  80. Iyer, V. R., C. E. Horak, C. S. Scafe, D. Botstein, M. Snyder, and P. O. Brown (2001). Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF Nature. 409: 533-8.PDF link
  81. Lieb, J. D., X. Liu, D. Botstein, and P. O. Brown (2001). Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association Nat Genet. 28: 327-334. PDF link
  82. Ranade, K., M. S. Chang, C. T. Ting, D. Pei, C. F. Hsiao, M. Olivier, R. Pesich, J. Hebert, Y. D. Chen, V. J. Dzau, D. Curb, R. Olshen, N. Risch, D. R. Cox, and D. Botstein (2001). High-throughput genotyping with single nucleotide polymorphisms Genome Res. 11: 1262-8.PDF link
  83. Sherlock, G., T. Hernandez-Boussard, A. Kasarskis, G. Binkley, J. C. Matese, S. S. Dwight, M. Kaloper, S. Weng, H. Jin, C. A. Ball, M. B. Eisen, P. T. Spellman, P. O. Brown, D. Botstein, and J. M. Cherry (2001). The Stanford Microarray Database. Nucleic Acids Res. 29: 152-5. PDF link
  84. Troyanskaya, O., M. Cantor, G. Sherlock, P. Brown, T. Hastie, R. Tibshirani, D. Botstein, and R. B. Altman (2001). Missing value estimation methods for DNA microarrays Bioinformatics 17: 520-5.PDF link
  85. S_rlie, T., Perou, C.M., Tibshirani, R., Aas, T., Geisler, D., Johnsen, H., Hastie, T., Eisen, M.B., van de Rijn, M., Jeffrey, S.S., Thorsen, T., Quist, H., Matese, J.C., Brown, P.O. Botstein, D., L_nning, P.E., B_rresen-Dale, A.-L. (2001). Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc. Natl. Acad.Sci. USA 98: 10869-74PDF link
  86. Finlin, B.S., Gau, C.L., Murphy, G.A., Shao, H., Kimel, T., Seitz, R.S., Chiu, Y.F., Botstein, D., Brown, P.O., Der, C.J., Tamanoi, F., Andres, D.A., Perou, C.M. (2001) Rerg is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer (2001) J. Biol. Chem. 52: 49244-50.PDF link
  87. Ranade K., Wu K.D., Hwu, C.M., Ting, C.T., Pei, D., Pesich, R., Hebert, J., Chen, Y.D., Pratt, R., Olshen, R., Masaki, K., Risch, N., Cox, D.R., Botstein, D. (2001). Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. Hum Mol Genet. 10: 2157-2164.PDF link
  88. Ranade ,K., Wu, K.D., Risch, N., Olivier, M., Pei D., Hsiao, C.F., Chuang, L.M, Ho, L.T., Jorgenson, E., Pesich, R., Chen, Y.D., Dzau, V., Lin, A., Olshen, R.A., Curb, D., Cox, D.R., and Botstein D. (2001) Genetic variation in aldosterone synthase predicts plasma glucose levels. Proc. Natl. Acad.Sci. (USA) 98: 13219-24.PDF link
  89. Anders KR, Botstein D. Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast. (2001) Mol Biol Cell. 12: 3973-86. PDF link
  90. Ranade K, Shue WH, Hung YJ, Hsuing CA, Chiang FT, Pesich R, Hebert J, Olivier M, Chen YD, Pratt R, Olshen R, Curb D, Botstein D, Risch N, Cox DR. The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin. (2001) Am J Hypertens. 14: 1196-200. PDF link
  91. Garber, M. E., Troyanskaya, O. G., Schluens, K., Petersen, S., Thasler, Z., Pacyna-Gengelbach, M., van de Rijn, M., Rosen,G. D., Perou, C.M. Whyte, R. I., Altman, R.B., Brown, P.O., Botstein, D., Petersen, I., (2001) Diversity of gene expression in adenocarcinoma of the lung Proc. Natl. Acad.Sci. (USA) 98: 13784-13789 .PDF link
  92. Rosenwald, A., Alizadeh, A.A., Widhopf, G., Simon, R., Davis, R. E., Yu, X., Yang, L., Pickeral, O. K., Rassenti, L. Z., Powell, J., Botstein, D., Byrd, J. C., Grever, M. R., Cheson, B. D., Chiorazzi, N., Wilson, W. H., Kipps, T. J., Brown, P. O., Staudt, L. M. (2001) Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J. Exp. Med. 194 :1639-47.PDF link
  93. Protchenko, O., Ferea, T., Rashford, J., Tiedeman, J., Brown, P. O., Botstein, D., Philpott, C. C., (2001) Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae. J. Biol. Chem. 52: 49244-50.PDF link
  94. Gasch, A.P., Huang, M., Metzner, S., Botstein, D., Elledge, S.J., Brown, P.O.,m (2001) Genomic Expression rsponse to DNA-damaging agents and the regulatory role of the yeast ATR homolog Meclp. Mol Biol. Cell 10: 2987-3003.PDF link
  95. Lonning P.E ., Sorlie T., Perou, C.M., Brown, P.O., Botstein, D, Borresen-Dale, A.L. (2001) Microarrays in primary breast cancer - lessons from chemotherapy studies. Endocr . Relat. Cancer 8:259-63.PDF link
  96. Richards, K.L., Anders, K.R., Nogales, E., Schwartz, K., Downing, K.H., Botstein, D. (2000) Structure-Function Relationships in Yeast Tubulins. Mol. Biol. Cell 11: 1887-1903.PDF link
  97. Ball, C.A., Dolinski, K., Dwight, S.S., Harris, M.A., Issel-Traver, L., Kasarskis, A., Scafe, C.R., Sherlock, G., Binkley, G., Jin, H., Kaloper, M., Orr, S.D., Schroeder, M., Wend, S., Zhu, Y., Botstein, D., Cherry, J.M. (2000) Intergrating Functional Genomic Information into the Saccharomyces Genome Database. Nucleic Acids Res. 28: 77-80.PDF link
  98. Ross, D.T., Scherf, U., Eisen, M.B., Perou, C.M., Spellman, P., Iyer, V., Jeffrey, S.S., Van de Rijn, M., Waltham, M., Pergamenschikov, A., Lee, J.C.F., Lashkari, D., Shalon, D., Myers, T.G., Weinstein, J.N., Botstein, D., Brown, P.O. (2000) Systematic Variation in Gene Expression Patterns in Human Cancer Cell Lines. Nat. Genet 24: 227-235.PDF link
  99. Scherf, U., Ross, D.T., Waltham, M., Smith, L.H., Lee, J.K., Kohn, K.W., Reinhold, W.C., Myers, T.G., Andrews, D.T., Scudiero, D.A., Eisen, M.B., Sausville, E.A., Pommier, Y., Botstein, D., Brown, P.O., Weinstein, J.N. (2000) A Gene Expression Database for the Molecular Pharmacology of Cancer. Nat. Genet. 24: 236-244.PDF link
  100. Alizadeh, A.A., Eisen, M.B., Davis, R.E., Ma, C., Lossos, I.S., Rosenwald, A., Boldrick, J.C., Sabet, H., Tran, T., Powell, J.I., Yang, L., Marti, G.E., Moore, T., Hudson, J., Lu, L., Lewis, D.B., Tibshirani, R., Sherlock, G., Chan, W.C., Greiner, T.C., Weisenburger, D.D., Armitage, J.O., Warnke, R., Levy, R., Wilson,W., Grever, M.R., Byrd, J.C., Botstein, D., Brown, P.O., Staudt, L.M. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profling. Nature 403: 503-511.PDF link
  101. Perou, C.M., Sorlie, T., Eisen, M.B., van de Rijn, M., Jeffrey, S.S., Rees, C.A., Pollack, J.R., Ross, D.T., Johnzsen, H., Akslen, L.A., Fluge, O., Pergamenschikov, A., Williams, C., Zhu, S.X., Lonning, P.E., Borrensen-Dale, A-L., Brown, P.O., Botstein, D. (2000) Molecular Portraits of Human Breast Tumors. Nature 406: 747-752.PDF link
  102. Zhu, G., Spellman, P.T., Volpe, T., Brown, P.O., Botstein, D., Davis, T.N., Futcher, B. (2000) Two yeast Forkhead Genes regulate the Cell Cycle and Pseudohyphal Growth. Nature 406: 90-94.PDF link
  103. Alter, O., Brown, P.O., Botstein, D. (2000) Singular value decomposition for genome-wide expression data processing and modeling. Proc. Natl. Acad.Sci. USA 97: 10101-6.PDF link
  104. Khodursky, A.B., Peter, B.J., Schmid, M.B., DeRisi, J., Botstein, D., Brown, P.O., Cozzarelli, N.R. (2000) Analysis of topoisomerase function in bacterial replication fork movement: Use of DNA microarrays. Proc. Natl. Acad.Sci. USA 97: 9419-9424.PDF link
  105. Ranade, K., Hsuing, A.C., Wu, K.D., Chang, M.S., Chen, Y.T., Hebert, J., Chen, Y.I., Olshen, R., Curb, D., Dzau, V., Botstein, D., Cox, D., Risch, N. (2000) Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. Am. J. Hypertens. 6: 704-709. PDF link
  106. Lyons, T.J., Gasch, A.P., Gaither, L.A., Botstein, D., Brown,P.O., Eide, D.J. (2000) Genome-wide characterization of the Zap 1p zinc-responsive regulon in yeast. Proc. Natl. Acad.Sci. USA 97: 7957-7962.PDF link
  107. Yun, C.W., Ferea, T., Rashford, J., Ardon, O., Brown, P.O., Botstein, D., Kaplan, J., Philpott, C.C. (2000) Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence two pathways of iron uptake. J. Biol. Chem. 275: 10709-10715.PDF link
  108. Friddle, C. Koskela R., Ranade, K., Hebert, J., Cargill, M., Clark, C.D., McInnis, M., Simpson, S, McMahon, F., Stine, O.C., Meyers, D., Xu, J., MacKinnon, D., Swift-Scanlan, T., Jamison, K., Folstein, S., Daly, M., Kruglyak, L., Marr, T., DePaulo, J.R., Botstein, D. (2000) Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am. J. Hum. Genet. 66: 205-215.PDF link
  109. Gasch, A.P., Spellman, P.T., Kao, C. M., Carmel-Harel, O., Storz, G., Botstein, D., Brown, P.O. (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell 11: 4241-57.PDF link
  110. Khodursky, A.B., Peter, B.J., Cozzarelli, N.R., Botstein, D., Brown, P.O., Yanofsky, C. (2000). DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli. Proc. Natl. Acad.Sci. USA 97: 9419-24PDF link
  111. Ashburner, M., C. A. Ball, J. A. Blake, D. Botstein, H. Butler, J. M. Cherry, A. P. Davis, K. Dolinski, S. S. Dwight, J. T. Eppig, M. A. Harris, D. P. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. C. Matese, J. E. Richardson, M. Ringwald, G. M. Rubin, and G. Sherlock (2000). Gene ontology: tool for the unification of biology. The Gene Ontology Consortium Nat. Genet. 25: 25-9.PDF link
  112. Diehn, M., M. B. Eisen, D. Botstein, and P. O. Brown (2000). Large-scale identification of secreted and membrane-associated gene products using DNA microarrays Nat Genet. 25: 58-62.PDF link
  113. Hastie, T., R. Tibshirani, M. B. Eisen, A. Alizadeh, R. Levy, L. Staudt, W. C. Chan, D. Botstein, and P. Brown (2000). 'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biol. 1 PDF link
  114. Lossos, I. S., A. A. Alizadeh, M. B. Eisen, W. C. Chan, P. O. Brown, D. Botstein, L. M. Staudt, and R. Levy (2000). Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas Proc. Natl. Acad.Sci. USA 97: 10209-13.PDF link
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  116. Alberts, B.M., Ayala, F.J., Botstein, D., Frank, E., Holmes, E.W., Lee, R.D., Macagno, E.R., Marrack, P., Oparil, S., Orkin, S.H., Ribenstein, A.H., Slayman, C.W., Sparling, P.F., Squire, L.R., von Hippel, P.H., Yamamoto, K.R. (2000) Proposed changes for NIH's Center for Scientific Review. Panel of Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science 285: 666-667. PDF link
  117. Lee SE, Pellicioli A, Demeter J, Vaze MP, Gasch AP, Malkova A, Brown PO, Botstein D, Stearns T, Foiani M, Haber JE. Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol. (2000);65:303-14. Review. No abstract available. PDF link
  118. Chervitz, S.A., Hester, E.T., Ball, C.A., Dolinski, K., Dwight, S.S., Harris M.A., Juvik, G., Malekian, A., Roberts, S., Roe, T.Y., Scafe, C., Schroeder, M., Sherlock, G., Weng, S., Zhu, Y., Cherry, J.M., Botstein, D. (1999) Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Res. 27: 74-78.PDF link
  119. Mulholland, J., Konopka, J., Singer-Kruger, B., Zerial, M. Botstein, D. (1999) Visualization of Receptor-mediated Endocytosis in Yeast. Mol. Biol. Cell 10: 799-817.PDF link
  120. Iyer, V.R., Eisen, M.B., Ross, D.T., Schuler, G., Moore, T., Lee, J.C.F., Trent, J.M., Staudt, L.M., Hudson, J., Boguski, M.S., Lashkari, D., Shalon, D., Botstein, D., Brown, P.O. (1999) The Transcriptional Program in Response of Human Fibroblasts to Serum. Science 283: 83-87.PDF link
  121. Pollack, J.R., Perou, C.M., Alizadeh, A., Eisen, M.B., Pergamenschikov, A., Williams, C.F., Jeffrey, S.S., Botstein, D., Brown, P.O. (1999) Genome-wide analysis of DNA copy number variation using cDNA microarrays. Nat. Genet. 23 :41-6. PDF link
  122. Ferea, T.L., Botstein, D., Brown, P.O., Rosenzweig, R.F. (1999) Systematic Changes in Gene Expression Patterns Following Adaptive Evolution in Yeast. Proc. Natl. Acad. Sci. (USA) 96: 9721-9726.PDF link
  123. Perou, C.M., Jeffrey, S.S., va de Rijn, M., Rees, C.A., Eisen, M.B., Ross, D.T., Pergamenshikov, A., Williams, C.F., Zhu, S.X., Lee, J.C.F., Lashkari, D., Shalon, D., Brown, P.O., Botstein, D. (1999) Distinctive Gene Expression Patterns in Human Mammary Epithelial Cells and Breast Cancers. Proc. Natl. Acad.Sci. USA 96: 9212-9217. PDF link
  124. Brown, P.O., Botstein, D. (1999) Exploring the new world of the genome with DNA microarrays. Nature Genet. 21: 33-37.PDF link
  125. Ferea, T., Dunn, B., Botstein, D., Brown, P.O. (1999) Genetic Footprinting and Functional Maps of the yeast Genome. In: PCR Applications: Protocols for Functional Genomics. Michael A. Innis, David H. Gelfand and John J. Sninsky, eds. Academic Press.PDF link
  126. Botstein, D. (1999) Of Genes and Genomes. In: Great Issues for Medicine in the Twenty-first Century. Dana Cook Grossman and Heinz Valtin eds. Ann. NY Acad. Sci. 882: 32-41.PDF link
  127. Cali, B.M., Doyle, T.C., Botstein, D., Fink, G.R. (1998) Multiple Functions for Actin During Filamentous Growth of Saccharomyces cerevisiae. Mol. Biol. Cell 9: 1873-1889.PDF link
  128. Cherry, J.M., Adler, C., Ball, C., Chervitz, S.A., Dwight, S.S., Hester,E.T., Jia, Y., Juvik, G., Roe, T., Schroeder, M., Weng, S., Botstein, D. (1998) SGD: Saccharomyces Genome Database. Nucleic Acids Res. 26: 73-79.PDF link
  129. Sekiya, M., Botstein, D., Ohya, Y. (1998) Identification of Functional Connections between Calmodulin and the Yeast Actin Cytoskeleton. Genetics 150: 43-58PDF link
  130. Spellman, P.T., Sherlock, G., Zhang, M.Q., Iyer, V.R., Anders, K., Eisen, M.B., Brown, P.O., Botstein, D., Futcher, B. (1998) Comprehensive Identification of Cell Cycle Regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization. Mol. Biol. Cell 9: 3273-3297.PDF link
  131. Pitti, R.M., Marsters, S.A., Lawrence, D.A., Roy, M., Kischkel, F., Dowd, P., Huang, A., Donahue, C.J., Sherwood, S.W., Baldwin D., Godowski, P., Wood, W.I., Gurney, A., Hillan, K.J., Cohen, R.L., Goddard, A.D., Botstein, D., Ashkenazi, A. (1998) Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 396: 699-702. PDF link
  132. Dolinski, K., Ball, C.A., Chervitz, S.A., Dwight, S.S., Harris, M.A., Roberts, S., Roe, T., Cherry, M., Botstein, D. (1998) Expanding Yeast Knowledge Online. Yeast 14: 1453-1469. PDF link
  133. Eisen, M., Spellman, P., Brown, P.O., Botstein, D. (1998) Cluster Analysis and Display of Genome-wide Expression Patterns. Proc. Natl. Acad.Sci. USA 95: 14863-14868.PDF link
  134. Chervitz, S.A., Koonin, E.V., Aravind, L., Ball, C.A., Dwight, S.S., Harris, M.A., Dolinski, K., Sherlock, G., Mohr, S., Smith, T., Cherry, J.M., Botstein, D. (1998) Comparing the Complete Genome Sequences of Worm and Yeast: Orthology and Divergence of Encoded Proteins. Science 282: 2022-2028. PDF link
  135. Chu, S., DeRisi, J., Mulholland, J., Botstein, D., Brown, P.O., Herskowitz, I. (1998) The Transcriptional Program of Sporulation in Budding Yeast. Science 282: 699-705.PDF link
  136. Pennica, D., Swanson, T.A., Welsh, J.W., Roy, M.A., Lawrence, D.A., Lee, J., Brush, J., Taneyhill, L.A.m Deuel, B., Lew, M., Watanabe, C., Cohen, R.L., Melham, M.F., Finley, G.G., Quirke, P., Goddard, A.D., Hillan, K.J., Gurney, A.L., Botstein, D., Levine, A.J. (1998) WISP Genes are New Members of the Connective Tissue Growth Factor Family that are Up-Regulated in Wnt-1 Transformed Cells and Aberrantly Expressed in Human Colon Tumors. Proc. Natl. Acad.Sci. USA 95: 14717-14722.PDF link
  137. Alizadeh, A., Eisen, M., Botstein, D., Brown, P.O., Staudt, L.M (1998) Probing Lymphocyte Biology by Genomic-Scale Gene Expression Analysis. J. Clin. Immunol. 18: 373-379. PDF link
  138. Cherry, J.M., Ball, C., Weng, S., Juvik, G., Schmidt, R., Adler, C., Dunn, B., Dwight, S., Riles, L., Mortimore, R.K., Botstein, D. (1997) Genetic and Physical Maps of Saccharomyces cerevisiae. Nature 387: 67-73. PDF link
  139. Amberg, D.C., Zahner, J.E., Mulholland, J.M., Pringle J.R., Botstein, D. (1997) Aip3p/Bud6p, a Yeast Actin-interacting Protein that is Involved in Morphogenesis and the Selection of Bipolar Budding Sites. Mol. Biol. Cell 8: 729-753.PDF link
  140. Mulholland, J.M., Botstein, D. (1997) Yeast actin cytoskeleton mutants accumulate a new class of golgi-derived secretory vesicle. Mol. Biol. Cell 8: 1481-1499.PDF link
  141. Schwartz, K., Richards, K., Botstein, D. (1997) BIM1 Encodes a Microtubule-Binding Protein in Yeast. Mol. Biol. Cell 8: 2677-2691.PDF link
  142. Dietrich, F. S., Mulligan, J., Hennessay, K., Yelton, M.A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J.M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R.W., Kayser, A., Komp, C.., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Nakahara, K., Namath, A., Norgren, R., Oefner, P., Oh, C., Petel, F.X., Roberts, D., Sehl, P., Schramm, S., Shogren, T., Smith, V., Taylor, P., Wei, Y., Botstein, D., Davis, R.W. (1997) The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Nature 387 (Suppl.): 78-81. PDF link
  143. Bussey, H., Storms, R.K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Aruajo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Brckner, M., Carpenter, J., Cherry, J.M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R.W., Dietrich, F.S., Delius,H., DiPaolo, T., Dubois, E., Dsterh”ft, A., Duncan, M., Floeth, M., Fortin, N., Friesen, J.D., Fritz, C., Goffeau, A., Hall, J., Hebling, U., Heumann, K., Hilbert, H., Hillier, L., and other member sof the Genome Sequencing Center, Hunicke-Smith, S., Hyman, R., Johnston, M., Kalman, S., Kleine, K., Komp, C., Kurdi, O., Lashkari, D., Lew, H., Lin, A., Lin, D., Louis, E.J., Marathe, R., Messenguy, F., Mewes, H.W., Mirtipati, S., Moestl, D., Mller-Auer, S., Namath, A., Nentwich, U., Oefner, P., Pearson, D., Petel, F.X., Pohl, T.M., Purnelle, B., Rajandream, M.A., Rechmann, S., Rieger, M., Riles, L., Roberts, D., Sch„fer, M., Scharfe, M., Scherens, B., Schramm, S., Schr”der, M., Sdicu, A.M., Tettelin, H., Urrestarazu, L.A., Ushinsky, S., Vierendeels, F., Vissers, S., Voss, H., Walsh, S.V., Wambutt, R., Wang, Y., Wedler, H., Wedler, H., Winnett, E., Zhong, W-W, Zollner, A., Vo, D.H., Hani, J. (1997) The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Nature 387 (Suppl.): 103-105. PDF link
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  145. Botstein, D., Amberg, D., Huffaker, T., Mulholland, J., Adams, A., Drubin, D., Stearns, T. (1997) The Yeast Cytoskeleton. In: Molecular and Cellular Biology of the Yeast Saccharomyces, vol.3. J.R. Broach, J.R. Pringle and E.W. Jones, eds. Cold Spring Harbor Press. PDF link
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  147. Botstein, D., Chervitz, S.A., Cherry, J.M. (1997) Yeast as a Model Organism. Science 277: 1259-1260.PDF link
  148. Amberg D. C., Botstein, D. (1997) Obtaining Structural Information about Protein Complexes with the Two-Hybrid System. In: The Yeast Two-Hybrid System. Paul L. Bartel and Stanley Fields, eds. Oxford University Press.PDF link
  149. Gschwend, M., Levran, O., Kruglyak, L., Ranade, K., Verlander, P.C., Shen, S., Faure, S., Weissenbach, J., Altay, C., Lander, E.S., Auerbach, A.D., Botstein, D. (1996) A Locus for Fanconi Anemia on 16q Determined by Homozygosity Mapping. Am. J. Hum. Genet. 59: 377-384. PDF link
  150. Doyle, T., Botstein, D. (1996) Movement of Yeast Cortical Actin Cytoskeleton Visualized in vivo. Proc. Natl. Acad. Sci. USA 93: 3886-3891.PDF link
  151. Miller, C.J., Doyle, T.C., Bobkova, E., Botstein, D., Reisler, E. (1996) Mutational Analysis of the Role of Hydrophobic Residues in the 338-348 Helix on Actin in Actomyosin Interactions. Biochemistry 35: 3670-3676.PDF link
  152. Smith, V., Chou, K.N., Lashkari, D., Botstein, D., Brown, P.O. (1996) Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting. Science 274: 2069-2074.PDF link
  153. Risch, N. and Botstein, D. (1996) A manic depressive history. Nature Genet. 12: 351-353.PDF link
  154. Amberg, D., Basart, E., Botstein, D. (1995) Defining protein interactions with yeast actin in vivo. Nat. Struct. Biol. 2: 28-35. PDF link
  155. Stine, O.C., Xu, J., Koskela, R., McMahon, F.J., Clark, C.D., Friddle, C., Gschwend, M., Breschel, T., Simpson, S.G., Botstein, D., Marr, T.G., McInnis, M.G., Meyers, D.A., DePaulo, J.R. (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am. J. Hum. Genet. 57: 1384-1394. PDF link
  156. Smith, V., Botstein, D., Brown, P.O. (1995) Genetic footprinting: A genomic strategy for determining a gene's function given its sequence. Proc. Natl. Acad. Sci. USA 92: 6479-6483.PDF link
  157. Amberg, D.C., Beasley, E.M., Botstein, D. (1995) Precise gene disruption in Saccharomyces cerevisiae by double fusion polymerase chain reaction. Yeast 11: 1275-1280. PDF link
  158. Botstein, D. (1995) Structure and Function of the Gene. In: Clinical Oncology. Martin D. Abeloff, James O. Armitage, Allen S. Lichter, John E. Niederhuber, eds. Churchill Livingstone, Inc.
  159. Ohya, Y., Botstein, D. (1994) Diverse Essential Functions Revealed by Complementing Yeast Calmodulin Mutants. Science 263: 963-966.PDF link
  160. Clark, C., Palzkill, T., Botstein, D. (1994) Systematic Mutagenesis of the Yeast Mating Pheromone Receptor Third Intracellular Loop. J. Biol. Chem. 269: 8831-8841.PDF link
  161. Keyt, B., Paoni, N., Refino, C., Berleau, L, Nguyen, H., Pater, C., Ogez, J., Etcheverry, T., Botstein, D., Bennett, W. (1994) A Faster-Acting and More Potent Form of Tissue Plasminogen Activator. Proc. Natl. Acad. Sci. USA 91: 3670-3674. PDF link
  162. Ziman, M., Preuss, D., Mulholland, J., O'Brien, J. M. , Botstein, D., Johnson, D. I. (1994) Subcellular Localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding Protein Involved in the Control of Cell Polarity. Mol. Biol. Cell 4: 1307-1316. PDF link
  163. Mulholland, J., Preuss, D., Moon, A., Wong, A., Drubin, D., Botstein, D. (1994) Ultrastructure of the Yeast Actin Cytoskeleton and Its Association with the Plasma Membrane. J. Cell Biol. 125: 381-391. PDF link
  164. Palzkill, T., Quyen-Quyen L., Wong, A., Botstein, D. (1994) Selection of Functional Signal Peptide Cleavage Sites from a Library of Random Sequences. J. Bacteriol. 176: 563-568. PDF link
  165. Ohya, Y., Botstein, D. (1994) Structure-Based Systematic Isolation of Conditional-Lethal Mutations in the Single Yeast Calmodulin Gene. Genetics 138: 1041-1054.PDF link
  166. Qadota, H., Anraku, Y., Botstein, D., Ohya, Y. (1994) Conditional lethality of a yeast strain expressing human RHOA in place of RHO1. Proc. Natl. Acad. Sci. USA 91: 9317-9321.PDF link
  167. Kolling, R., Lee, A., Chen, E.Y., Botstein, D. (1994) Nucleotide Sequence of the SAC2 Gene of Saccharomyces cerevisiae. Yeast 10: 1211-1216. PDF link
  168. Kolling, R., Nguyen, T., Chen, E. Y., Botstein, D. (1993) A new yeast gene with a myosin-like heptad repeat stucture. Mol. Gen. Genet. 237: 359-369. PDF link
  169. Dunn, B., Stearns, T., Botstein, D. (1993) Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4. Nature 362: 563-565.PDF link
  170. Winey, M., Hoyt, M. A., Chan, C., Goetsch, L., Botstein, D., Byers, B. (1993) NDC1: A Nuclear Periphery Component Required for Yeast Spindle Pole Body Duplication. J. Cell Biol. 122: 743-752.PDF link
  171. Ohya, Y., Qadota, H., Anraku, Y., Pringle, J. R., Botstein, D. (1993) Suppression of Yeast Geranylgeranyl Transferase I Defect by Alternative Prenylation of Two Target GTPases, Rho1p, and Cdc42p. Mol. Biol. Cell 4: 1017-1025.PDF link
  172. Chan, C. S. M., Botstein, D. (1993) Isolation and Characterization of Chromosome-Gain and Increase-in-Ploidy Mutants in Yeast. Genetics 135: 667-691.PDF link
  173. Botstein, D. (1993) Genetics in the Post-Sequence Era. Trends in Genetics April, p. 101. PDF link
  174. Botstein, D. (1993) A Phage Geneticist Turns to Yeast. In: The Early Days of Yeast Genetics. Michael N. Hall and Patrick Linder, eds. Cold Spring Harbor Laboratory Press, Publishers.
  175. Barnes, G., Louie, K.A. and Botstein, D. (1992). Yeast Proteins Associated with Microtubules in vitro and in vivo. Mol. Biol. Cell 3: 29-47.PDF link
  176. Kron, S.J., Drubin, D.G., Botstein, D. and Spudich, J.A. (1992). Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin. Proc. Natl. Acad. Sci. USA 89 4466-4470.PDF link
  177. Palzkill, T. and Botstein, D. (1992). Probing _-Lactamase Structure and Function Using Random Replacement Mutagenesis. Proteins: 14 29-44.PDF link
  178. Preuss, D., Mulholland, J., Franzusoff, A., Segev, N., Botstein, D.(1992) Characterization of the Saccharomyces Golgi Complex Through the Cell Cycle by Immunoelectron Microscopy. Mol. Biol. Cell 3 789-803. PDF link
  179. Paoni, N.F., Refino, C.J., Brady, K., Pena, L.C., Nguyen, H.V., Kerr, E.M., Johnson, A.C., Wurm, F.M., van Reis, R., Botstein, D. and Bennett, W.F.(1992) Involvement of Residues 296-299 in the Enzymatic Activity of Tissue-type Plasminogen Activator. Protein Eng. 5 259-266.
  180. Wertman, K.F., Drubin, D.G., and Botstein, D. (1992) Systematic Mutational Analysis of the Yeast ACT1 Gene. Genetics 132 337-350.PDF link
  181. Palzkill, T., Botstein, D. (1992) Identification of Amino Acid Substitutions that Alter the Substrate Specificity of TEM-1 b-Lactamase. J. Bacteriol. 174 5237-5243. PDF link
  182. Manolson, M.F., Proteau, D., Preston, R.A., Stenbit, A., Roberts, B.T., Hoyt, M.A., Preuss, D., Mulholland, J., Botstein, D., Jones, E.W. (1992) The VPH1 Gene Encodes a 95-kDA Integral Membrane Polypeptide Required for in vivo Assembly and Activity of the Yeast Vacuolar H+-ATPase. J. Biol. Chem. 267: 14294-303.PDF link
  183. Chen, Y, Hennessy, K. M., Botstein, D., Tye, B. (1992) CDC46/MCM5, a Yeast Protein whose Subcellular Localization is Cell Cycle-regulated, is Involved in DNA Replication at Autonomously Replicating Sequences. Proc. Natl. Acad. Sci. USA 89: 10459-10463PDF link
  184. Botstein, D (1992) Genetics Society of America Medal: Maynard V. Olson. Genetics 131: (supplement) S11-12.
  185. Bennett, W.F., Paoni, N.F., Keyt, B.A., Botstein, D., Jones, A.J.S., Presta, L., Wurm, F.M. and Zoller, M.J. (1991). High-Resolution Analysis of Functional Determinants on Human Tissue-Type Plasminogen Activator. J. Biol. Chem 266: 5191-5201.PDF link
  186. Hennessy, K.M., Lee, A., Chen, E. and Botstein, D. (1991). A Group of Interacting Yeast DNA Replication Genes. Genes Dev. 5: 958-969. PDF link
  187. States, D.J. and Botstein, D. (1991). Molecular Sequence Accuracy and the Analysis of Protein Coding Regions. Proc. Natl. Acad. Sci. USA 88: 5518-5522.PDF link
  188. Froelich, K.U., Fries, H.W., Rudiger, M., Erdmann, R., Botstein, D. and Mecke, D. (1991). Yeast Cell Cycle Protein CDC48p Shows Full-Length Homology to the Mammalian Protein VCP and is a Member of a Protein Family Involved in Secretion, Peroxisome Formation, and Gene Expression. J. Cell Biol. 114: 443-453. PDF link
  189. Adams, A.E.M., Botstein, D.and Drubin, D.G. (1991). Requirement of yeast fimbrin for actin organization and morphogenesis in vivo. Nature 354: 404-408.PDF link
  190. Preuss, D., Mulholland, J., Kaiser, C.A., Orlean, P., Albright, C., Rose, M.D., Robbins, P.W. and Botstein, D. (1991). Structure of the Yeast Endoplasmic Reticulum: Localization of ER proteins using Immunofluorescence and Immunoelectron Microscopy. Yeast 7: 891-911. PDF link
  191. Botstein, D. (1991) Why yeast? Hospital Practice (Office Edition) 26: 157-61, 164.
  192. Botstein, D. (1991). Linkage Genetics in Humans: Origins and Prospects. In: Etiology of Human Disease at the DNA Level. Jan Lindsten and Ulf Pettersson, eds. Raven Press, Ltd.
  193. Hennessy, K.M. and Botstein, D. (1991). Regulation of DNA Replication during the Yeast Cell Cycle. Cold Spring Harbor Symp. Quant. Biol. 56: 279-284.
  194. Stearns, T., Ma, H. and Botstein, D. (1991) Manipulating Yeast Genome Using Plasmid Vectors. In: Gene Expression Technology. David V. Goeddel, Editor. Academic Press, Inc. Harcourt Brace Jovanovich, Publishers. PDF link
  195. Drubin, D.G., Mulholland, J., Zhu, Z. and Botstein, D. (1990). Homology of a Yeast Actin-Binding Protein to Signal Transduction Proteins and Myosin-I. Nature 343: 288-290.PDF link
  196. Baker, D., Wuestehube, L., Schekman, R., Botstein, D. and Segev, N. (1990). GTP-binding Protein Ypy1 Protein and Ca2+ Function Independently in a Cell-Free Transport Reaction. Proc. Natl. Acad. Sci. USA 87: 355-359.PDF link
  197. Stearns, T., Hoyt, M.A. and Botstein, D. (1990). Yeast Mutants Sensitive to Antimicrotubule Drugs Define Three Genes that Affect Microtubule Function. Genetics 124: 251-262.PDF link
  198. Kaiser, C.A. and Botstein, D. (1990). Efficiency and Diversity of Protein Localization by Random Signal Sequences. Mol. Cell. Biol. 10: 3163-3173.PDF link
  199. Stearns, T., Willingham, M.C., Botstein, D. and Kahn, R. (1990). ADP-ribosylation Factor is Functionally and Physically Associated with the Golgi Complex. Proc. Natl. Acad. Sci. USA 87: 1238-1242. >PDF link
  200. Hoyt, M.A., Stearns, T. and Botstein, D. (1990). Chromosome Instability Mutants of Saccharomyces cerevisiae That Are Defective in Microtubule-Mediated Processes. Mol. Cell. Biol. 10: 223-234.PDF link
  201. Kunes, S., Botstein, D. and Fox, M.S. (1990). Synapsis-Mediated Fusion of Free DNA Ends Forms Inverted Dimer Plasmids in Yeast. Genetics 124: 67-80.PDF link
  202. Hennessy, K.M., Clark, C.D. and Botstein, D. (1990). Subcellular Localization of Yeast CDC46 Varies with the Cell Cycle. Genes Dev. 4: 2252-2263. PDF link
  203. Stearns T., Kahn R.A. Botstein, D. and Hoyt M.A. (1990). ADP Ribosylation Factor is an Essential Protein in Saccharomyces cerevisiae and is Encoded by Two Genes. Mol. Cell. Biol. 10: 6690-6699. PDF link
  204. Botstein, D. (1990). 1989 Allen Award Address: The American Society of Human Genetics Annual Meeting, Baltimore. Am. J. Hum. Genet. 47: 887-891. PDF link
  205. Lander, E.S. and Botstein, D. (1989) Mapping Mendelian Factors Underlying Quantitative Traits Using RFLP Linkage Maps. Genetics 121: 185-194.PDF link
  206. Preuss, D. and Botstein, D. (1989) Intragenic Revertants of Yeast Invertase Variants with Secretion-Defective Leader Sequences. Mol. Cell. Biol. 9: 1452-1464.PDF link
  207. Novick, P., Osmond, B.C. and Botstein, D. (1989) Suppressors of Yeast Actin Mutations. Genetics 121: 659-674.PDF link
  208. Adams, A.E.M. and Botstein (1989). Dominant Suppressors of Yeast Actin Mutations That Are Reciprocally Suppressed. Genetics 121: 675-683.PDF link
  209. Adams, A.E.M., Botstein, D. and Drubin, D.G. (1989) A Yeast Actin-Binding Protein is Encoded by SAC6, a Gene Found by Suppression of an Actin Mutation. Science 243: 231-233.PDF link
  210. Ma, H., Bloom, L.M., Dakin, S.E., Walsh, C.T. and Botstein, D. (1989) The 15 N-Terminal Amino Acids of Hexokinase II Are Not Required for in vivo Function: Analysis of a Truncated Form of Hexokinase II in Saccharomyces cerevisiae. Proteins 5: 218-223. PDF link
  211. Ma, H., Bloom, L.M., Zhu, Z., Walsh, C.T. and Botstein, D. (1989). Isolation and Characterization of Mutations in the HXK2 Gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 9: 5630-5642.PDF link
  212. Ma, H., Bloom, L.M., Walsh, C.T. and Botstein, D. (1989). The Residual Enzymatic Phosphorylation Activity of Hexokinase II Mutants is Correlated with Glucose Repression in Saccharomyces cerevisiae. Mol. Cell. Biol. 9: 5643-5649. PDF link
  213. Holm, C., Stearns, T. and Botstein, D. (1989) DNA Topoisomerase II Must Act at Mitosis to Prevent Nondisjunction and Chromosome Breakage. Mol. Cell. Biol. 9: 159-168.PDF link
  214. Lander, E.S. and Botstein, D. (1989) Accurate and Efficient Mapping of Quantitative Trait Loci in Development and Application of Molecular Markers to Problems in Plant Genetics. In: Plant RFLPs (T. Helentjaris and B. Burr, eds.) Cold Spring Harbor Press, pp. 89-96.PDF link
  215. Olson, M., Hood, L., Cantor, C., and Botstein, D. (1989). A Common Language for Physical Mapping of the Human Genome. Science 245: 1434-1435.PDF link
  216. Schumm, J.W., Knowlton, R.G., Braman, J.C., Barker, D.F., Botstein, D., Akots, G, Brown, V.A., Gravius, T.C., Helms, C., Hsiao, K. et al. (1988) Identification of More Than 500 RFLPs by Screening Random Genomic Clones. Am. J. Hum. Genet. 42: 143-159. PDF link
  217. Segev, N., Mulholland, J. and Botstein, D. (1988) The Yeast GTP-Binding YPT1 Protein and a Mammalian Counterpart Are Associated with the Secretion Machinery. Cell 52: 915-924. PDF link
  218. Stearns, T. and Botstein, D. (1988) Unlinked Noncomplementation: Isolation of New Conditional-Lethal Mutations in Each of the Tubulin Genes of Saccharomyces cerevisiae. Genetics 119: 249-260.PDF link
  219. Daub, E., Zawadzke, L.E., Botstein, D. and Walsh, C.T. (1988) Isolation, Cloning, and Sequencing of the Salmonella typhimurium dd1A Gene with Purification and Characterization of its Product, D-Alanine:D-Alanine Ligase (ADP Forming). Biochemistry 27: 3701-3708. PDF link
  220. Huffaker, T.C., Thomas, J.H. and Botstein, D. (1988) Diverse Effects of b-Tubulin Mutations on Microtubule Formation and Function. J. Cell Biol. 106: 1997-2010.PDF link
  221. Schatz, P.J., Solomon, F. and Botstein, D. (1988) Isolation and Characterization of Conditional-Lethal Mutations in the TUB1 a-Tubulin Gene of the Yeast Saccharomyces cerevisiae. Genetics 120: 681-695.PDF link
  222. Drubin, D.G., Miller, K.G. and Botstein, D. (1988). Yeast Actin-binding Proteins: Evidence for a Role in Morphogenesis. J. Cell Biol. 107: 2551-2561.PDF link
  223. Botstein, D. and Fink, G. (1988) Yeast: An Experimental Organism for Modern Biology. Science 240: 1439-1443.PDF link
  224. Donis-Keller, H. and Botstein, D. (1988) Recombinant DNA Methods: Applications to Human Genetics. Prog. Med. Genet. 7: 17-42.
  225. Drubin, D. and Botstein, D. (1988) Molecular Genetic Analysis of the Yeast Actin Cytoskeleton. Gene Expression and Regulation: The Legacy of Luigi Gorini.PDF link
  226. Botstein, D. (1988) Why Study the Cytoskeleton in Yeast? Harvey Lectures.87: 157-167.PDF link
  227. Botstein, D., Segev, N., Stearns, T., Hoyt, M.A., Holden, J. and Kahn, R.A. (1988) Diverse Biological Functions of Small GTP-Binding Proteins in Yeast. Cold Spring Harbor Symp. Quant. Biol. 53: 629-636.PDF link
  228. Alberts, B.M., Botstein, D., Brenner, S., Cantor, C.R., Doolittle, R.F., Hood, L., McKusick, V.A., Nathans, D., Olson, M.V., Orkin, S., Rosenberg, L.E., Ruddle, F.H., Tilghman, S., Tooze, J., & Watson, J.D. (1988) Report of the Committee on Mapping and Sequencing the Human Genome. Board on Basic Biology, Commission on Life Sciences, National Research Council. National Academy Press, Washington, D.C.
  229. Kunes, S., Ma, H., Overbye, K., Fox, M.S. and Botstein, D. (1987) Fine Structure Recombinational Analysis of Cloned Genes Using Yeast Transformation. Genetics 115: 73-81.PDF link
  230. Thomas, James H. and Botstein, David (1987) Ordered Linear Tetrads Are Produced by the Sporulation of Newly Formed Zygotes of Saccharomyces cerivisiae. Genetics 115: 229-232. PDF link
  231. Kaiser, C.A., Preuss, D., Grisafi, P. and Botstein, D. (1987) Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase. Science 235: 312-317.PDF link
  232. Huisman, O., Raymond, W., Frohlich, K., Errada, P., Kleckner, N., Botstein, D. and Hoyt, M.A. (1987) A Tn10-lacZ-kanR-URA3 Gene Fusion Transposon For Insertion Mutagenesis and Fusion Analysis of Yeast and Bacterial Genes. Genetics 116: 191-199.PDF link
  233. Donis-Keller, H., Green, P., Helms, Cartinhour, S., Weiffenbach, B., Stephens, K., Keith, T.P., Bowden, D.W., Smith, D.R., Lander, E.S., Botstein, D., et al. (1987) A Genetic Linkage Map of the Human Genome. Cell 51: 319-337. PDF link
  234. Riggs, P.D. and Botstein, D. (1987) Bacteriophage P22 Gene 23 Product Acts Preferentially in cis. J. Virology 61: 2316-2318.PDF link
  235. Segev, N. and Botstein, D. (1987) The ras-Like Yeast YPT1 Gene is Itself Essential for Growth, Sporulation, and Starvation Response. Mol. Cell. Biol. 7: 2367-2377.PDF link
  236. Fitts, R., Reuveny, Z., Van Amsterdam, J., Mulholland, J. and Botstein, D. (1987) Substitution of Tyrosine for Either Cysteine in b-lactamase Prevents Release From the Membrane During Secretion. Proc. Nat. Acad. Sci. USA 84: 8540-8543.PDF link
  237. Rose, M.D., Novick, P., Thomas, J.H., Botstein, D. and Fink, G.R. (1987) A Saccharomyces cerevisiae Genomic Plasmid Bank Based on a Centromere-Containing Shuttle Vector. Gene 60: 237-243. PDF link
  238. Ma, H., Kunes, S., Schatz, P.J. and Botstein, D. (1987) Plasmid Construction by Homologous Recombination in Yeast. Gene 58: 201-216. PDF link
  239. Schatz, P.J., Georges, G.E.; Solomon, F. and Botstein, D. (1987) Insertions of Up to 17 Amino Acids Into a Region of a-tubulin Do Not Disrupt Function in vivo. Mol. Cell. Biol. 7: 3799-3805.PDF link
  240. Riggs, P.D. and Botstein, D. (1987) Fusions of Bacteriophage P22 Late Genes to the Escherichia coli lacZ Gene. J.Virology 61: 3621-3624. PDF link
  241. Lander, E.S. and Botstein, D. (1987) Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children. Science 236: 1567-1570.PDF link
  242. Huffaker, T.C., Hoyt, M.A. and Botstein, D. (1987) Genetic Analysis of the Yeast Cytoskeleton. Ann. Rev. Genet. 21: 259-284.PDF link
  243. Thomas, J.H. and Botstein, D. (1986) A Gene Required for Separation of Chromosomes on the Spindle Apparatus in Yeast. Cell 44: 65-76. PDF link
  244. Vergnaud, G., Page, D.C., Simmler, M., Brown, L., Rouyer, F., Noel, B., Botstein, D., de la Chapelle, A. and Weissenbach, J. (1986) A Deletion Map of the Human Y Chromosome based on DNA Hybridization. Am. J. Hum. Genet. 38: 109-124. PDF link
  245. Holm, C., Wagner, D.W., Fangman, W.L. and Botstein, D. (1986) A Rapid, Efficient Method for Isolating DNA from Yeast. Gene 42: 169-173. PDF link
  246. Kaiser, C. and Botstein, D. (1986) Secretion-Defective Mutations in the Signal Sequence for Saccharomyces cerevisiae Invertase. Mol. Cell. Biol. 6: 2382-2391.PDF link
  247. Stachelek, C., Stachelek, J., Swan, J., Botstein, D.and Konigsberg, W. (1986) Identification, Cloning and Sequence Determination of Genes Specifying Hexokinase A and B from Yeast. Nucleic Acids Res. 14: 945-963.PDF link
  248. Schatz, P.J., Pillus, L., Grisafi, P., Solomon, F. and Botstein, D. (1986) Two Functional a-tubulin Genes of the Yeast Saccharomyces cerevisiae Encode Divergent Proteins. Mol. Cell. Biol. 6: 3711-3721.PDF link
  249. Schatz, P.J., Solomon, F. and Botstein, D. (1986) Genetically Essential and Nonessential a-tubulin Genes Specify Functionally Interchangeable Proteins. Mol. Cell. Biol. 6: 3722-3733. PDF link
  250. Ma, H. and Botstein, D. (1986) The Effects of Null Mutations in the Hexokinase Genes of Saccharomyces cerevisiae on Catabolite Repression. Mol. Cell. Biol. 6: 4046-4052.PDF link
  251. Wertman, K.F., Wyman, A.R. and Botstein, D. (1986) Host/Vector Interactions Which Affect the Viability of Recombinant Phage Lambda Clones. Gene 49: 253-262.
  252. Galakatos, N.G., Daub, E., Botstein, D. and Walsh, C.T. (1986) Biosynthetic alr Alanine Racemase From Salmonella typhimurium: DNA and Protein Sequence Determination. Biochemistry 25: 3255-3260. PDF link
  253. Brissenden, D.C., Page, D.C., de Martinville, J., Trowsdale, J., Botstein, D.and Francke, U. (1986) Regional Assignments of Three Polymorphic DNA Segments on Human Chromosome 15. Genet. Epidemiol. 3: 231-239. PDF link
  254. Lander, Eric S. and Botstein, David (1986) Strategies For Studying Heterogeneous Genetic Traits in Humans by Using a Linkage Map of Restriction Fragment Length Polymorphisms. Proc. Nat. Acad. Sci. USA 83: 7353-7357.PDF link
  255. Thomas, J.H., Novick, P. and Botstein, D. (1984) Genetics of the Yeast Cytoskeleton. In: Molecular Biology of the Cytoskeleton (G.G. Bomsy, D.W. Cleveland and D.B. Murphy, eds.), Cold Spring Harbor Laboratory Press, New York, pp. 153-174. Also republished (1986) as Genetics of the Yeast Cytoskeleton. Yeast Cell Biology (J. Hicks, ed.), Alan R. Liss, New York, pp. 13-44.
  256. Botstein, D. (1986) The Molecular Biology of Color Vision. Science 232: 142-143.PDF link
  257. Lander, E. and Botstein, D. (1986) Mapping Complex Genetic Traits in Humans: New Methods Using A Complete RFLP Linkage Map. Cold Spring Harbor Laboratory Symp. Quant. Biol. 51: 49-62.PDF link
  258. Lander, E. and Botstein, D. (1986) Consanguinity and Heterogeneity: Cystic Fibrosis Need Not be Homogeneous in Italy. Am. J. Hum. Genet. 39: 282-283.PDF link
  259. Kunes, S., Botstein, D. and Fox, M.S. (1985) Transformation of Yeast With Linearized Plasmid DNA: Formation of Inverted Dimers and Recombinant Plasmid Products. J.Mol.Biol. 184: 375-387. PDF link
  260. Wyman, A.R., Wolfe, L. and Botstein, D. (1985) Propagation of Some Human DNA Sequences in Bacteriophage l Vectors Requires Escherichia coli Hosts. Proc. Natl. Acad. Sci. USA 82: 2880-2884.PDF link
  261. Novick, P. and Botstein, D. (1985) Phenotypic Analysis of Temperature-Sensitive Yeast Actin Mutants. Cell 40: 405-416.PDF link
  262. Holm, C., Goto, T., Wang, J.C. and Botstein, D. (1985) DNA Topoisomerase II is Required at the Time of Mitosis in Yeast. Cell 41: 553-563.PDF link
  263. Thomas, J.H., Neff, N. and Botstein, D. (1985) Isolation and Characterization of Mutations in the b-tubulin Gene of Saccharomyces cerevisiae. Genetics 112: 715-734. PDF link
  264. Botstein, D. (1985) Considerations Affecting the Feasibility of Mapping a Single-Gene Disorder Using Restriction Fragment Polymorphisms, With Special Reference to Ataxia Telangiectasia. Ataxia-Telangiectasia, pp. 125-131.PDF link
  265. Shortle, D. and Botstein, D. (1985) Strategies and Applications of in vitro Mutagenesis. Science 229:4719, 1193-1201. PDF link
  266. Botstein, D. (1985) Mapping the Human Genome Using Restriction Fragment Length Polymorphisms. Genetics and the Law, pp. 97-105.PDF link
  267. Carlson, M., Osmond, B.C., Neigeborn, L. and Botstein, D. (1984) A Suppressor of SNF1 Mutations Causes Constitutive High-Level Invertase Synthesis in Yeast. Genetics 107: 19-32.PDF link
  268. Maurer, R., Osmond, B.C., Shekhtman, E., Wong, A. and Botstein, D. (1984) Functional Interchangeability of DNA Replication Genes in Salmonella typhimurium and Escgerichia coli Demonstrated by a General Complementation Procedure. Genetics 108: 1-23. PDF link
  269. Maurer, R., Osmond, B.C. and Botstein, D. (1984) Genetic Analysis of DNA Replication in Bacteria: DNAB mutants that suppress DNAC Mutations and DNAQ Mutations That Suppress DNAE Mutations in Salmonella typhimurium. Genetics 108: 25-38.PDF link
  270. Rose, M., Grisafi, P. and Botstein, D. (1984) Structure and Function of the Yeast URA3 Gene: Expression in Escherichia coli. Gene 29: 113-124. PDF link
  271. Shortle, D., Novick, P. and Botstein, D. (1984) Construction and Genetic Characterization of Temperature-Sensitive Mutant Alleles of the Yeast Actin Gene. Proc. Natl. Acad. Sci. USA 81: 4889-4893.PDF link
  272. Page, D.C., Harper, M.E., Love, J. and Botstein, D. (1984) Occurrence of a Transposition From the X-Chromosome Long Arm to the Y-Chromosome Short Arm During Human Evolution. Nature 311: 119-123. PDF link
  273. Wasserman, S., Daub, E., Grisafi, P., Botstein, D. and Walsh, C. (1984) Catabolic Alanine Racemase From Salmonella typhimurium: DNA Sequence, Enzyme Purification, and Characterization. Biochemistry 23: 5182-5187. PDF link
  274. Novick, P., Thomas, J.H. and Botstein, D. (1984) Genetic Analysis of Cytoskeletal Protein Function in Yeast. In Genetic Engineering, Principles and Methods, Vol. 6, (A. Hollaender and J.K. Setlow, eds.), pp. 211-231.
  275. Botstein, D. and Donis-Keller, H. (1984) A Molecular Approach to Defining the Inherited Components in Epilepsy and Other Diseases of Uncertain Etiology. Epilepsia 25 (suppl. 2): S150-S155.
  276. Kunes, S., Botstein, D. and Fox, M.S. (1984) Formation of Inverted Dimer Plasmids After Transformation of Yeast With Linearized Plasmid DNA. Cold Spring Harbor Symp. Quant. Biology 49: 617-628.
  277. Wasserman, S.Z., Walsh, C.T. and Botstein, D. (1983) Two Alanine Racemase Genes in Salmonella typhimurium That Differ in Structure and Function. J. Bacteriol. 153: 1439-1450.PDF link
  278. Carlson, M. and Botstein, D. (1983) Organization of the SUC Gene Family in Saccharomyces. Mol. Cell. Biol. 3: 351-359. PDF link
  279. Carlson, M., Taussig, R., Kustu, S. and Botstein, D. (1983) The Secreted Form of Invertase in Saccharomyces cerevisiae is Synthesized From mRNA Encoding a Signal Sequence. Mol. Cell. Biol. 3: 439-447.PDF link
  280. Neff, N., Thomas, J. and Botstein, D. (1983) Isolation of the b-tubulin Gene From Yeast and Demonstration of its Essential Function in vivo. Cell 33: 211-219.PDF link
  281. Falco, C., Rose, M. and Botstein, D. (1983) Homologous Recombination Between Episomal Plasmids and Chromosomes in Yeast. Genetics 105: 843-856. PDF link
  282. Falco, C. and Botstein, D. (1983) A Rapid Chromosome Mapping Method for Cloned Fragments of Yeast DNA. Genetics 105: 857-872. PDF link
  283. Rose, M. and Botstein, D. (1983) Structure and Function of the Yeast URA3 Gene: Differentially Regulated Expression of Hybrid b-Galactosidase From Overlapping Coding Sequences in Yeast. J. Mol. Biol. 170: 883-904. PDF link
  284. Shortle, D. and Botstein, D. (1983) Directed Mutagenesis With Sodium Bisulfite. Meth.Enzymol. 100: 457-468. PDF link
  285. Rose, M. and Botstein, D. (1983) Construction and Use of Gene Fusions to lacZ (b-galactosidase) Which Are Expressed in Yeast. Meth.Enzymol. 101: 167-180. PDF link
  286. Campbell, A. and Botstein, D. (1983) Evolution of the Lamboid Phages. In Lambda II (R.W. Hendrix, J.W. Roberts, F.W. Stahl and R.A. Weisberg, eds.), Cold Spring Harbor Laboratory Press, N.Y., pp. 365-380.
  287. Page, D., Wyman, A. and Botstein, D. (1983) Homologous Single-Copy Sequences on the Human X and Y Chromosomes. In Banbury Report 14: Recombinant DNA Applications to Human Disease. Cold Spring Harbor Laboratory Press, N.Y., pp. 267-273.
  288. Carlson, M. and Botstein, D. (1982) Two Differentially Regulated mRNAs with Different 5' Ends Encode Secreted and Intracellular Forms of Yeast Invertase. Cell 28: 145-154. PDF link
  289. Moir, D., Stewart, S.E., Osmond, B.C. and Botstein, D. (1982) Cold-Sensitive Cell-Division-Cycle Mutants of Yeast: Isolation, Properties and Pseudoreversion Studies. Genetics 100: 565-577.PDF link
  290. Moir, D. and Botstein, D. (1982) Determination of the Order of Gene Function in Yeast Nuclear Division Pathway Using cs and ts Mutants. Genetics 100: 547-563. PDF link
  291. Shortle, D., Grisafi, P., Benkovic, S.J. and Botstein, D. (1982) Gap Misrepair Mutagenesis: Efficient Site-Directed Induction of Transition, Transversion and Frameshift Mutations in vitro. Proc. Natl. Acad. Sci. USA 79: 1588-1592.PDF link<
  292. Falco, S.C., Li, Y., Broach, J.R. and Botstein, D. (1982) Genetic Properties of Chromosomally Integrated 2m Plasmid DNA in Yeast. Cell 29: 573-584.PDF link
  293. Shortle, D., Haber, J.E. and Botstein, D. (1982) Lethal Disruption of the Yeast Actin Gene by Integrative DNA Transformation. Science 217: 371-373. PDF link
  294. Koshland, D. and Botstein, D. (1982) Evidence for Post-Translational Translocation of b-lactamase Across the Bacterial Inner Membrane. Cell 30: 893-902.PDF link
  295. Koshland, D., Sauer, R.T. and Botstein, D. (1982) Diverse Effects of Mutations in the Signal Sequence on the Secretion of b-lactamase in Salmonella typhimurium. Cell 30: 903-914.PDF link
  296. Page, D., de Martinville, B., Barker, D., Wyman, A., White, R., Francke, U. and Botstein, D. (1982) Single-Copy Sequence Hybridizes to Polymorphic and Homologous Loci on the Human X and Y Chromosomes. Proc. Natl. Acad. Sci.USA 79: 5352-5357.PDF link
  297. Silverman, S., Rose, M., Botstein, D. and Fink, G.R. (1982) Expression of a HIS4-lacZ Gene Fusion in Saccharomyces cerevisiae. Mol. Cell. Biol. 2: 1212-1219.PDF link
  298. Ibe, S.N., Sinskey, A.J. and Botstein, D. (1982) Genetic Mapping of Mutations in a Highly Radiation-Resistant Mutant of Salmonella typhimurium LT2. J. Bacteriol. 152: 260-268.PDF link
  299. Macaluso, A., Midthun, K., Bender, R.A. and Botstein, D. (1982) Nonsense Suppressor Mutants of Bacteriophage T5. Virology 117: 275-279. PDF link
  300. Botstein, D. and Davis, R.W. (1982) Principles and Practice of Recombinant DNA Research With Yeast. In Molecular Genetics of Yeast Saccharomyces: Metabolism and Gene Expression (E.W. Jones, J. Broach and J.N. Strathern, eds.), Cold Spring Harbor Laboratory Press, N.Y., pp. 607-636.PDF link
  301. Botstein, D., Shortle, D. and Rose, M. (1982) Making Mutations in vitro and Putting Them Back Into Yeast. In From Gene to Protein: Translation into Biotechnology (F. Ahmad, J. Schultz, E.E. Smith and W.J. Whelan, eds.), Academic Press, N.Y., pp. 265-274.PDF link
  302. Botstein, D. and Maurer, R. (1982) Genetic Approaches to the Analysis of Microbial Development. Ann.Rev.Genetics 16: 61-83.PDF link
  303. Botstein, D., Shortle, D. and Rose, M. (1982) Making and Using Mutations in Cloned Genes. In Perspectives on Genes and the Molecular Biology of Cancer (D.L. Robberson and G.F. Saunders, eds.), Raven Press, pp. 81-90.PDF link
  304. Winston, F. and Botstein, D. (1981) Control of Lysogenization by Phage P22. I. The P22 cro Gene. J. Mol. Biol. 152: 209-232. PDF link
  305. Winston, F. and Botstein, D. (1981) Control of Lysogenization by Phage P22. II. Mutations (clyA) in the c1 Gene that Cause Increased Lysogenization. J. Mol. Biol. 152: 233-245.
  306. Rose, M., Casadaban, M.J. and Botstein, D. (1981) Yeast Genes Fused to b-galactosidase in Escherichia coli can be Expressed Normally in Yeast. Proc. Natl. Acad. Sci. USA 78: 2460-2464.PDF link
  307. Carlson, M., Osmond, B.C. and Botstein, D. (1981) Mutants of Yeast Defective in Sucrose Utilization. Genetics 98: 25-40.PDF link
  308. Carlson, M., Osmond, B.C. and Botstein, D. (1981) Genetic Evidence for a Silent SUC Gene in Yeast. Genetics 98: 41-54. PDF link
  309. Carlson, M., Osmond, B. and Botstein, D. (1981) The SUC Genes of Yeast: A Dispersed Gene Family. Cold Spring Harbor Symp. Quant. Biol. 45: 799-803. PDF link
  310. Lacroute, F., Bach, M.L., Chevallier, M.R., Hubert, J.C., Losson, R., Botstein, D. and Loison, D. (1981) Transcriptional Regulation of the Yeast Pyrimidine Genes. In Molecular Genetics of Yeast (D. von Wettstein, J. Friis, M. Kielland-Brandt and A. Stenderup, eds.), Alfred Benzon Symposium 16, Munksgaard, Copenhagen.
  311. Shortle, D. and Botstein, D. (1981) Single-Stranded Gaps as Localized Targets For in vitro Mutagenesis. In Molecular and Cellular Mechanisms of Mutagenesis (J.F. Lemontt and W.M. Generos, eds.), Plenum Press, N.Y., pp. 147-156. PDF link
  312. Maurer, R., Osmond, B.C. and Botstein, D. (1981) Genetic Analysis of DNA Replication in Salmonella typhimurium. ICN-UCLA Symp. Mol.Cell.Biol. 21: 375-386.
  313. Botstein, D., White, R.L., Skolnick, M. and Davis, R.W. (1980) Construction of a Genetic Linkage Map in Man Using Restriction Fragment Length Polymorphisms. Am. J. Hum. Genet. 32: 314-331. PDF link
  314. Botstein, D. (1980) A Theory of Modular Evolution for Bacteriophages. Ann. N.Y. Acad. Sci. 354: 484-491. PDF link
  315. Weinstock, G.M., Riggs, P.D. and Botstein, D. (1980) Genetics of Bacteriophage P22. III. The Late Operon. Virology 106: 82-91. PDF link
  316. Weinstock, G.M. and Botstein, D. (1980) Genetics of Bacteriophage P22. IV. Correlation of Genetic and Physical Map Using Translocatable Drug-Resistance Elements. Virology 106: 92-99. PDF link
  317. Koshland, D. and Botstein, D. (1980) Secretion of Beta-Lactamase Requires the Carboxyl End of the Protein. Cell 20: 749-760.PDF link
  318. O'Brien, T.F., Ross, D.G., Guzman, M.A., Medeiros, A.A., Hedges, R.W. and Botstein, D. (1980) Dissemination of an Antibiotic Resistance Plasmid in Hospital Patient Flora. Antimicrob. Agents Chemother. 17: 537-543.PDF link
  319. Botstein, D. (1980) A Modular Theory of Virus Evolution. ICN-UCLA Symp. Mol.Cell.Biol. 18: 11-20.
  320. Bach, M.L., Lacroute, F. and Botstein, D. (1979) Evidence for Transcriptional Regulation of Orotidine-5'-Phospate-Decarboxylase in Yeast by Hybridization mRNA to the Yeast by Structural Gene Cloned in Escherichia coli. Proc. Natl. Acad. Sci. USA 76: 386-390.PDF link
  321. Kleckner, R., Reichart, K. and Botstein, D. (1979) Inversions and Deletions of Salmonella Chromosome Generated by the Translocatable Tetracycline-Resistance Element Tn10. J. Mol. Biol. 127: 89-115.PDF link
  322. Winston, F., Botstein, D. and Miller, J.H. (1979) Characterization of Amber and Ochre Suppressors in Salmonella typhimurium. J. Bacteriol. 137: 433-439.PDF link
  323. Kleckner, N., Steele, D.A., Reichardt, K. and Botstein, D. (1979) Specificity of Insertion by the Translocatable Tetracycline Resistance Element Tn10. Genetics 92: 1023-1040.PDF link
  324. Poteete, A.R., Jarvik, V. and Botstein, D. (1979) Encapsulation of Phage P22 DNA in vitro. Virology 95: 550-564.
  325. Poteete, A.R. and Botstein, D. (1979) Purification and Properties of Proteins Essential to DNA Encapsulation by Phage P22. Virology 95: 565-573.
  326. Botstein, D. and Poteete, A.R. (1979) Formation of P22 Generalized Transducing Particles in vitro. Virology 95: 574-576.
  327. Weinstock, G.M., Susskind, M.M. and Botstein, D. (1979) Regional Specificity of Illegitimate Recombination by the Translocatable Ampicillin-Resistance Element Tn1 in the Genome of Phage P22. Genetics 92: 685-710.PDF link
  328. Botstein, D., Falco, S.C., Stewart, S., Brennan, M., Scherer, S., Stinchcomb, D.T., Struhl, K. and Davis, R. (1979) Sterile Host Yeasts (SHY): A Eukaryotic System of Biological Containment for Recombinant DNA Experiments. Gene 8: 17-24.
  329. Ross, D.G., Grisafi, P., Kleckner, N. and Botstein, D. (1979) The Ends of Tn10 Are Not IS3. J. Bacteriol. 139: 1097-1101.PDF link
  330. Susskind, M.M. and Botstein, D. (1979) Superinfection Exclusion by l Prophage in Lysogens of Salmonella typhimurium. Virology 100: 212-216.
  331. Weinstock, G.M. and Botstein, D. (1979) Regional Specificity of Illegitimate Recombination Associated With the Translocatable Ampicillin-Resistance Element Tn1. Cold Spring Harbor Symp. Quant. Biol. 43: 1209-1215.PDF link
  332. Moir, D., Stewart, S.E. and Botstein, D. (1979) Analysis of Yeast Cell-Cycle Mutations by Pseudo-Reversion. ICN-UCLA Symp. Mol.Cell.Biol. 14: 85-93.
  333. Campbell, A., Starlinger, P., Berg, D.E., Botstein, D., Lederberg, E.M., Novick, R.P. and Szybalski, W. (1979) Nomenclature of Transposable Elements in Prokaryotes. Plasmid 2: 466-473; Gene 5: 197-206.
  334. Kleckner, N., Barker, D.F., Ross, D.G., Botstein, D., Swan, J.A. and Zabeau, M. (1978) Properties of the Translocatable Tetracycline-Resistance Element Tn10 in Escherichia coli and Bacteriophage Lambda. Genetics 90: 427-467.PDF link
  335. Susskind, M.M. and Botstein, D. (1978) Repression and Immunity in Salmonella Phages P22 and L: Phage L Lacks a Functional Secondary Immunity System. Virology 89: 618-622.PDF link
  336. Petes, T.D., Broach, J.R., Wensink, P.C., Hereford, L.M., Fink, G.R. and Botstein, D. (1978) Isolation and Analysis of Recombinant DNA Molecules Containing Yeast DNA. Gene 4: 37-49.
  337. Susskind, M.M. and Botstein, D. (1978) The Molecular Genetics of Bacteriophage P22. Microbiol. Rev. 42: 385-413.PDF link
  338. Kleckner, N., Roth, J. and Botstein, D. (1977) Genetic Engineering in vivo Using Translocatable Drug-Resistance Elements: New Methods in Bacterial Genetics. J. Mol. Biol. 116: 125-159.
  339. Petes, T.D. and Botstein, D. (1977) Simple Mendelian Inheritance of the Reiterated Ribosomal DNA of Yeast. Proc. Natl. Acad. Sci. USA 74: 5091-5095.PDF link
  340. Botstein, D. and Kleckner, N. (1977) Translocation and Illegitimate Recombination by the Tetracycline Resistance Element Tn10. In DNA Insertion Elements, Plasmids and Episomes (S. Adhya, A. Bukhari and J. Shapiro, eds.), Cold Spring Harbor Laboratory Press, N.Y., pp. 185-203.
  341. King, J., Botstein, D., Casjens, S., Earnshaw, W., Harrison, S. and Lenk, E. (1977) Structure and Assembly of the Capsid of Bacteriophage P22. Phil. Trans. R. Soc. Lond. B. 276: 37-49.
  342. Petes, T.D., Hereford, L.M. and Botstein, D. (1977) Simple Mendelian Inheritance of the Repeating Yeast Ribosomal RNA Genes. Cold Spring Harbor Symp. Quant. Biol. 42: 1201-1207.PDF link
  343. Campbell, A., Berg, D., Botstein, D., Lederberg, E., Novick, R., Starlinger, P. and Szybalski, W. (1977) Nomenclature of Transposable Elements in Prokaryotes. In DNA Insertion Elements, Plasmids and Episomes (S. Adhya, A. Bukhari and J. Shapiro, eds.), Cold Spring Harbor Laboratory Press, N.Y., pp. 15-22.
  344. Petes, D., Hereford, L.M. and Botstein, D. (1977) Organization of Yeast Ribosomal DNA. ICN-UCLA Symp. Mol. Cell Biol. 8: 239-246.PDF link
  345. Brandriss, M.C., Stewart, J.W., Sherman, F. and Botstein, D. (1976) Substitution of Serine Caused by a Recessive Lethal Suppressor in Yeast. J. Mol. Biol. 102: 467-476.
  346. Gesteland, R.F., Wolfner, M., Grisafi, P., Fink, G., Botstein, D. and Roth, J.R. (1976) Yeast Suppressors of UAA and UAG Nonsense Codons Work Efficiently in vitro Via tRNA. Cell 7: 381-390.PDF link
  347. Hilliker, S. and Botstein, D. (1976) Specificity of Genetic Elements Controlling Regulation of Early Functions in Temperate Bacteriophages. J. Mol. Biol 106: 537-566.
  348. Chan, R.K. and Botstein, D. (1976) Specialized Transduction by Bacteriophage P22 in Salmonella typhimurium: Genetic and Physical Structure of the Transducing Genomes and the Prophage Attachment Site. Genetics 83: 433-458.PDF link
  349. Botstein, D., Lew, K.K., Jarvik, V.M. and Swanson, C.A., Jr. (1975) Role of Antirepressor in the Bipartite Control of Repression and Immunity by Bacteriophage P22. J. Mol. Biol. 91: 439-462.
  350. Jarvik, J. and Botstein, D. (1975) Conditional-Lethal Mutations That Suppress Genetic Defects in Morphogenesis by Altering Structural Proteins. Proc. Natl. Acad. Sci. USA 72: 2738-2742.PDF link
  351. Kleckner, N., Chan, R.K., Tye, B.K. and Botstein, D. (1975) Mutagenesis by Insertion of a Drug-Resistance Element Carrying an Inverted Repetition. J. Mol. Biol. 97: 561-575.
  352. Susskind, M.M. and Botstein, D. (1975) Mechanism of Action of Salmonella Phage P22 Antirepressor. J. Mol. Biol. 98: 413-424.
  353. Hilliker, S. and Botstein, D. (1975) An Early Regulatory Gene of Salmonella Phage P22 Analogous to Gene N of Coliphage Lambda. Virology 68: 510-524.
  354. Brandriss, M.C., Soll, L. and Botstein, D. (1975) Recessive Lethal Amber Suppressor in Yeast. Genetics 79: 551-560.PDF link
  355. Roberts, J.W., Roberts, C.W., Hilliker, S. and Botstein, D. (1975) Transcription Termination and Regulation in Bacteriophage P22 and Lambda. In RNA Polymerase (M. Chamberline and R. Losick, eds.), Cold Spring Harbor Laboratory Press, N.Y., pp. 707-718.
  356. Tye, B.K., Chan, R.K. and Botstein, D. (1974) Packaging of an Oversize Transducing Genome by Salmonella Phage P22. J. Mol. Biol. 85: 485-500.
  357. Tye, B.K., Huberman, J.A. and Botstein, D. (1974) Non-random Circular Permutation of Phage P22 DNA. J. Mol. Biol. 85: 501-527.
  358. Young, I.T., Levinstone, D., Eden, M., Tye, B.K. and Botstein, D. (1974) Appendix: Alignment of Partial Denaturation Maps of Circularly Permuted DNA by Computer. J. Mol. Biol. 85: 528-532.
  359. Botstein, D. and Herskowitz, I. (1974) Properties of Hybrids Between the Salmonella Phage P22 and Coliphage Lambda. Nature 251: 584-589.
  360. Susskind, M.M., Botstein, D. and Wright, A. (1974) Superinfection Exclusion by P22 Prophage in Lysogens of Salmonella typhimurium. III. Failure of Superinfecting Phage DNA to Enter sieA+ Lysogens. Virology 62: 350-366.
  361. Susskind, M.M., Wright A. and Botstein, D. (1974) Superinfection Exclusion by P22 Prophage in Lysogens of Salmonella typhimurium. IV. Genetics and Physiology of sieB Exclusion. Virology 62: 367-384.
  362. Tye, B.K. and Botstein, D. (1974) P22 Morphogenesis II. Mechanisms of DNA Encapsulation. J. Supramolecular Structure 2: 225-238.9.
  363. Botstein, D. and Susskind, M.M. (1974) Regulation of Lysogens and the Evolution of Temperate Bacterial Viruses. In Mechanisms of Virus Disease (W.S. Robinson & C.F. Fox, eds.) W.A. Benjamin, pp. 363-384.
  364. Davies, R., Sinskey, A.J. and Botstein, D. (1973) Deoxyribonucleic Acid Repair in a Highly Radiation-Resistant Strain of Salmonella typhimurium. J. Bacteriol. 114: 357-366.PDF link
  365. Jarvik, J. and Botstein, D. (1973) A Genetic Method for Determining the Order of Events in a Biological Pathway. Proc. Natl. Acad. Sci. USA 70: 2046-2050.PDF link
  366. Botstein, D., Waddescp /Users/sam/Desktop/SGD-to.gif /Genomics/lsi/www/html/botstein/botstein_sam/Icons/ ll, C.H. and King, J.A. (1973) Mechanism of Head Assembly and DNA Encapsulation of Phage P22. I. Genes, Proteins, Structures, and DNA Maturation. J. Mol. Biol. 80: 669-695.
  367. King, J.A., Lenk, E.H. and Botstein, D. (1973) Mechanism of Head Assembly and DNA Encapsulation of Phage P22. II. Morphogenetic Pathway. J. Mol. Biol. 80: 697-731.
  368. Chan, R.K. and Botstein, D. (1972) Genetics of Bacteriophage P22. I. Isolation of Prophage Deletions Which Affect Immunity to Superinfection. Virology 49: 257-267.
  369. Botstein, D., Chan, R.K. and Waddell, C.H. (1972) Genetics of Bacteriophage P22. II. Gene Order and Gene Function. Virology 49: 268-282.
  370. Ebel-Tsipis, J., Botstein, D. and Fox, M.S. (1972) Generalized Transduction by Phage P22 in Salmonella typhimurium. I. The Molecular Origin of Transducing DNA. J. Mol. Biol. 71: 433-448.
  371. Ebel-Tsipis, J., Fox, M.S. and Botstein, D. (1972) Generalized Transduction by Phage P22 in Salmonella typhimurium. II. Mechanisms of Integration of Transducing DNA. J. Mol. Biol. 71: 449-469.
  372. Watanabe, T., Ogata, Y., Chan, R.K. and Botstein, D. (1972) Specialized Transduction of Tetracycline Resistance by Phage P22 in Salmonella typhimurium. I. Transduction of R Factor 222 by P22. Virology 50: 874-882.
  373. Chan, R.K., Botstein, D., Watanabe, T. and Ogata, Y. (1972) Specialized Transduction of Tetracycline Resistance by Phage P22 in Salmonella typhimurium. II. Properties of a High-Frequency Transducing Lysate. Virology 50: 883-898.
  374. Ebel-Tsipis, J. and Botstein, D. (1971) Superinfection Exclusion by P22 Prophage in Lysogens of Salmonella typhimurium I. Exclusion of Generalized Transducing Particles. Virology 45: 629-652.
  375. Susskind, M., Wright, A. and Botstein, D. (1971) Superinfection Exclusion by P22 Prophage in Lysogens of Salmonella typhimurium. II. Genetic Evidence for Two Exclusion Systems. Virology 45: 629-637.
  376. Botstein, D. and Matz, M.J. (1970) A Recombination Function Essential to the Growth of Bacteriophage P22. J. Mol. Biol. 54: 417-440
  377. Botstein, D. and Jones, E.W.(1969) Non-random Mutagenesis of the E. coli Genome by Nitrosoguanidine. J. Bacteriol. 98: 847-848.PDF link
  378. Botstein, D. (1968) Synthesis and Maturation of Phage P22 DNA. I. Identification of Intermediates. J. Mol. Biol. 34: 621-643.
  379. Botstein, D. and Levine, M. (1968) Synthesis and Maturation of Phage P22 DNA. II. Properties of Temperature-Sensitive Phage Mutants Defective in DNA Metabolism. J. Mol. Biol. 34: 643-654.
  380. Botstein, D. and Levine, M. (1968) Intermediates in the Synthesis of Phage P22 DNA. Cold Spring Harbor Symp. Quant. Biol. 33: 659-667.
  381. Botstein, D. (1967) Sedimentation Analysis of Replicating Phage P22 DNA. Bacteriol.Proc. 161. PDF link
    382.

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