Rabinowitz Lab

Publications
38. Lu, W., Kwon, Y., Rabinowitz, J.D. (2007). Isotope ratio-based profiling of microbial folates. J. Am. Soc. Mass Spectr. (in press). [Epub ahead of print]

37. Campagna, S., Rabinowitz, J. D. (2007). Metabolome quantitation mass spectrometry. G.I.T. Laboratory Journal (in press).

36. Rabinowitz, J. D. (2007). Cellular metabolomics of Escherichia coli. Exp. Rev. Proteomics (in press).

35. Xavier, K. B., Miller, S. T., Lu, W., Kim, J. H., Rabinowitz, J. D., Pelczer, I., Semmelhack, M. F., Bassler, B. L. (2007). Phosphorylation and processing of the quorum-sensing molecule AI-2 in enteric bacteria. ACS Chem. Biol. 2:128-136. PubMed

34. Avram, M. J., Henthorn, T. K., Spyker, D. A., Krejcie, T. C., Lloyd, P. M., Cassella, J. V., Rabinowitz, J. D. (2006). Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug. Metab. Dispos. (in press).

33. Bao Q, Lu W, Rabinowitz JD, Shi Y (2007). Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Mol Cell 25: 181-192. PubMed

32. Brauer, M. J., Yuan, J., Bennett, B. D., Kimball, E., Botstein, D., Rabinowitz, J. D. (2006). Conservation of the metabolic response to starvation across two divergent microbes. Proc. Natl. Acad. Sci. USA 103: 19302-19307. PubMed

31. Munger, J., Bajad, S. U., Coller, H. A., Shenk, T., Rabinowitz, J. D. (2006). Dynamics of the Cellular Metabolome during Human Cytomegalovirus Infection. PLoS Pathog. (12):e132 [Epub ahead of print]

30. Hess, D. C., Lu, W., Rabinowitz, J. D., Botstein, D. (2006). Ammonium toxicity and potassium limitation in yeast. PLOS Biology 4: e351. PubMed

29. Kimball E, Rabinowitz J. D. (2006). Identifying decomposition products in extracts of cellular metabolites. Anal. Biochem. PubMed

28. Myers, D. J., Timmons, R. D., Lu, A. T., Hale, R. L., Solas, D. W., Soni, P., Rabinowitz, J. D. Thermal Aerosol Generation I. Effect of Film Thickness. Pharm. Res. 24:336-42. PubMed

27. Yuan, J., Fowler, W., Kimball, E. H., Lu, W., Rabinowitz, J. D. (2006). Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nat. Chem. Biol. 2:529-530. PubMed

26. Rabinowitz J.D., Lloyd PM, Munzar P, Myers DJ, Cross S, Damani R, Quintana R, Spyker DA, Soni P, Cassella JV (2006). Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J. Pharm. Sci. 95: 2438-2451 PubMed

25. Bajad SU, Lu W, Kimball EH, Yuan J, Peterson C, Rabinowitz J. D. (2006). Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J. Chromatogr. A 1125: 76-88. PubMed

24. Lu W, Kimball E, Rabinowitz J. D. (2005). A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J. Am. Soc. Mass. Spectrom. 17: 37-50. PubMed

23. Rabinowitz, J. D., Wensley, M., Lloyd, P., Myers, D., Shen, W., Lu, A., Hodges, C., Hale, R., Mufson, D., Zaffaroni, A. (2004). Fast onset medications through thermally generated aerosols. J. Pharmacol. Exp. Ther., 309:769-75. PubMed

22. Hall, F., Rabinowitz, J., Busch, R., Visconti, K., Belmares, M., Patil, N., Cope, A., Patel, S., McConnell, H., Mellins, E., Sonderstrup, G. (2002). Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. Eur. J. Immunol. 32: 662-70. PubMed

21. Patil, N.S., Pashine, A., Belmares, M.P., Liu, W., Kaneshiro, B., Rabinowitz, J., McConnell, H., Mellins, E.D. (2001). Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles. J. Immunol. 167:7157-68. PubMed

20. Belmares, M. P., Rabinowitz, J. D., Lui, W., Mellins, E. D., McConnell, H. M. (2000). pH stability of HLA-DR4 complexes with antigenic peptides. Biochemistry 39: 14558-66. PubMed

19. Kasson, P. M., Rabinowitz, J. D., Schmitt, L., Davis, M. M., McConnell, H. M. (2000). Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry 39: 1048-58. PubMed

18. Rabinowitz, J. D., Vrljic, M., Kasson, P. M., Liang, M. N., Busch, R., Boniface, J. J., Davis, M. M., McConnell, H. M. (1998). Formation of a highly peptide-receptive state of class II MHC. Immunity 9: 699-709. PubMed

17. Boniface, J. J., Rabinowitz, J. D., Wulfing, C., Hampl, J., Reich, Z., Altman, J. D., Kantor, R. M., Beeson, C., McConnell, H. M., Davis, M. M. (1998). Initiation of signal transduction through the T cell receptor requires the peptide multivalent engagement of MHC ligands. Immunity 9: 459-66. PubMed

16. Lee, C., Liang, M. N., Tate, K. M., Rabinowitz, J. D., Beeson, C., Jones, P. P., McConnell, H. M. (1998). Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft. J. Exp. Med. 187: 1505-1516. PubMed

15. Rabinowitz, J. D., Vacchino, J., Beeson, C., McConnell, H. M. (1998). Potentiometric measurement of intracellular redox activity. J. Am. Chem. Soc. 120: 2464-2473.

14. Petros, W. P., Rabinowitz, J., Gibbs, J.P., Hall, I. H., Stuart, A. R., Peters, W. P. (1998). Effect of plasma TNF-alpha on filgrastim-stimulated hematopoiesis in mice and humans. Pharmacotherapy 18: 816-23.

13. Rabinowitz, J. D., Tate K., Lee C., Beeson C., McConnell H. M. (1997). Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA 94: 8702-8707. PubMed

12. Rabinowitz, J.D., Rigler P., Carswell-Crumpton, C., Beeson, C., McConnell, H. M. (1997). Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade. Life Sci. 61: PL87-PL94. PubMed

11. Elkordy, M., Crump, M., Vredenburgh, J. J., Petros, W. P., Hussein, A., Rubin, P., Ross, M., Gilbert, C., Modlin, C., Meisenberg, B., Coniglio, D., Rabinowitz, J., Laughlin, M., Kurtzberg, J., Peters, W. P. (1997). A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation. Bone Marrow Transpl. 19: 315-322.

10. Petros, W. P., Rabinowitz, J., Stuart, A., Peters W. P. (1997). Clinical pharmacology of filgrastim following high-dose chemotherapy and autologous bone marrow transplantation. Clin. Cancer Res. 3: 705-11.

9. Wulfing, C., Rabinowitz, J. D., Beeson C., Sjaastad M. D., McConnell H. M., Davis M. M. (1997). Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med. 185: 1815-1825. PubMed

8. Rabinowitz, J. D., Beeson, C., Wulfing C., Tate K., Allen P. M., Davis M. M., McConnell, H. M. (1996). Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity 5: 125-135. PubMed

7. Rabinowitz, J. D., Beeson C., Lyons D. S., Davis M. M., McConnell, H. M. (1996). Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA 93: 1401-1405. PubMed

6. Beeson, C., Rabinowitz, J., Tate, K., Gutgemann, I., Chien, Y. H., Jones, P. P., Davis, M. M., McConnell, H. M. (1996). Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. J. Exp. Med. 184: 777-82.

5. Petros, W. P., Rosner, G. L., Rabinowitz, J., Gilbert, C. J., Coniglio, D., Vredenburgh J. J., Ross, M., Peters, W. P. (1996). The pharmacologic effects of recombinant, human colony-stimulating factors and their modulation by theophylline. Pharmacotherapy 16: 742-748.

4. Petros W. P., Rabinowitz, J., Stuart A. R., Gupton C., Peters, W. P. (1994). Elevated endogenous serum macrophage colony-stimulating factor in the early stage of fungemia following bone marrow transplantation. Exp. Hematol. 22: 582-586.

3. Rabinowitz, J., Petros, W. P. (1994). Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials. Cancer Bulletin 46: 40-47.

2. Rabinowitz, J., Petros, W. P., Stuart, A. R., Peters, W. P. (1993). Characterization of endogenous cytokine concentrations following high-dose chemotherapy with autologous bone marrow support. Blood 81: 2452-2459.

1. Petros W. P., Rabinowitz, J., Stuart, A., Peters, W. P. (1992). Disposition of recombinant human granulocyte-macrophage colony stimulating factor in patients undergoing autologous bone marrow transplantation. Blood 80: 1135-40.

INVITED TALKS

2006    Chinese American Chemical Society Symposium on Biological Mass Spectrometry, Rutgers University

2006    Symposium on Metabolomics and Diabetes, University of Michigan

2006    Symposium on Predictive Models of Complex Systems, Center of Cell Dynamics, University of Washington

2006    American Society of Mass Spectrometry Annual Meeting, Seattle

2005    Joint Academic - Bristol Myers Squibb Research Symposium, Princeton University

2005    Microbial Systems Biology Research Symposium, Princeton University

2004    Department of Chemistry, Princeton University

2002    Lewis-Sigler Institute for Integrative Genomics, Princeton University

2000    Center for Genomics Research, Harvard University

1999    Whitehead Center for Genome Research, Massachusetts Institute of Technology

1997 International Symposium on Microphysiometry and Cellular Screening, Paris

CONFERENCE PRESENTATIONS

7. Rabinowitz, J., Vrljic, M., Kasson, P., Davis, M. M., McConnell, H. M. (1999). Formation of a Highly Peptide-Receptive State of Class II MHC. Poster presented at Keystone Symposium on Tolerance and Autoimmunity, Keystone, CO.

6. Rabinowitz, J., Vacchino, J., Beeson, C., McConnell, H. M. (1996). Effects of signal transduction cascades on cellular redox state. Poster presented at Stanford University Annual Immunology Conference, Asilomar, CA. Award for best poster presentation.

5. Rabinowitz, J., Petros, W. P., Reisner, E. G., Berry, D., Stuart, A., Peters, W. P. (1994). Analysis of factors affecting platelet transfusion requirements following high-dose chemotherapy with autologous bone marrow support. Blood 84(suppl 1): 492a. Poster presented at American Society of Hematology Meeting, Nashville, TN.

4. Rabinowitz, J., Petros, W. P., Stuart, A., Gupton, C., Alderman, E. M., Peters, W. P. (1992). Serum macrophage colony-stimulating factor concentrations are elevated in patients with fungal infections. Blood 80(suppl 1): 419a. Poster presented at American Society of Hematology Meeting, Anaheim, CA.

3. Rabinowitz, J., Petros, W. P., Stuart, A. R., Crawford, E., Peters, W. P. (1991). Organ toxicity associated with endogenous cytokine secretion after high-dose chemotherapy and autologous bone marrow support. Pharmacotherapy 11: 282. Poster presented at American College of Clinical Pharmacy Meeting, Minneapolis, MN.

2. Rabinowitz, J., Stuart, A., Petros, W. P., Peters, W. P. (1990). Endogenous cytokine secretion after high-dose chemotherapy with autologous bone marrow support. Blood 76(suppl 1): 162a. Poster presented at American Society of Hematology Meeting, Boston, MA.

1. Rabinowitz, J., Stuart, A., Peters, W. P. (1990). Pharmacokinetics of recombinant granulocyte- macrophage colony stimulating factor following high-dose chemotherapy and autologous bone marrow transplantation. Poster presented at American Association for Cancer Research Meeting, Washington, D. C.