Modeling pattern formation and morphogenesis
The main focus of our work is on the quantitative analysis of development. Our goal is to establish models that connect multiple levels of description, from gene sequence to pattern formation and morphogenesis. We emphasize close coupling between genetic experiments, computations, and theory, and use the fruit fly as an experimental system for model validation. Current projects include genome-wide studies of signaling in the Drosophila ovary, parameter estimation for morphogen gradients, and quantitative analysis of feedback control in pattern formation.