Senior Research Associate, Storey Lab
Lewis-Sigler Institute for Integrative Genomics
Princeton University
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Michael Hudock, Ph.D. Senior Research Associate, Storey Lab Lewis-Sigler Institute for Integrative Genomics Princeton University |
Ph.D., Biophysics & Computational Biology (2008)My Work:
Dissertation: Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach
University of Illinois at Urbana-Champaign (Eric Oldfield, Advisor)
Associate Research Scientist (2001-2003)
Discovery Technologies Group
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT.
B.S., Biochemistry (2001) (w/ Computer Science & Information Systems)
Susquehanna University, Selinsgrove, PA.
My work focuses on the design and implementation of computational, statistical and informatics methods for the genomics and chemistry fields.
I am currently working to describe the relationship between gene expression and certain epigenetic features specifically in the context of cell differentiation (part of ENCODE). Additionally, as part of a large-scale clinical study (Gluegrant), I am developing novel methods to search for patterns in high dimensional datasets. More specifically, gene expression changes occuring as a result of inflammation due to trauma.
Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation
Zhang, Y., Cao, R., Yin, F., Hudock, M.P., et al.
J. Am. Chem. Soc.2009 131, 5153-5162.
DOI: 10.1021/ja808285e
Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation
Hudock, M.P., Chen, C.K.M., Zhang, Y., et al.
J. Med. Chem. 2008 51, 5594-5607.
DOI: 10.1021/jm800325
Activity of Sulfonium Bisphosphonates on Tumor Cell Lines
Zhang, Y.H., Hudock, M.P., Krysiak, K., et al.
J. Med. Chem. 2007 50, 6067-6079.
DOI: 10.1021/jm700991k
Bisphosphonates Target Multiple Sites in both cis- and trans-prenyltransferases
Guo, R.T., Cao, R., Liang, P.H., Ko, T.P., Chang, T.H., Hudock, M.P., et al.
Proc. Nat. Acad. Sci. U.S.A. 2007 104 10022-10027
DOI: 10.1073/pnas.0702254104
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates
Hudock, M.P., Sanz-Rodriguez, C.E., Song, Y.C., et al.
J. Med. Chem. 2006 49 215-223.
DOI: 10.1021/jm0582625
Isoprenoid biosynthesis as a drug target: Bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin
Leon, A., Yang, Y., Hudock, M.P., et al.
J. Med. Chem. 2006 49 7331-7341.
DOI: 10.1021/jm060492b
Solid-state NMR, crystallographic, and computational investigation of Bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes
Mao, J.H., Mukherjee, S., Zhang, Y., Cao, R., Sanders, J.M., Song, Y.C., Zhang, Y.H., Meints, G.A., Gao, Y.G., Mukkamala, D., Hudock, M.P. and Oldfield, E.
J. Am. Chem. Soc. 2006 128 14485-14497.
DOI: 10.1021/ja061737c