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Systems Biology of Regulatory Networks

The research in our laboratory is focused on a central problem in biology—how genetic information maps to phenotype. We work on 1) transcriptional networks, where DNA regulatory elements dictate the primary manifestation of phenotype—that of expressing genes into mRNA, and 2) on genetic networks, where complex interactions between gene products underlie the ultimate expression of phenotype.  We make extensive use of traditional experimental methods, including molecular biology, microbial physiology, and biochemistry.  In addition, we develop and employ novel technologies for making genome-wide measurements, together with computational and analytic tools required to turn these observations into plausible models of the underlying biology.  Our goal is to achieve a predictive understanding of biological behavior in terms of the structural and dynamical properties of the underlying molecular networks. To learn more...

Saeed Tavazoie
Associate Professor
Department of Molecular Biology
& The Lewis-Sigler Institute for Integrative Genomics
Princeton University

 
Last updated 8/9/06